Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. HPLC of Formula: C8H9NO2. Introducing a new discovery about 22013-33-8, Name is 2,3-Dihydrobenzo[b][1,4]dioxin-6-amine
Synthesis of some 1, 4-benzodioxane containing methanesulfonamides and their hemolytic study on human blood
The aim of this work was to synthesize some methanesulfonamides bearing 1, 4- benzodioxane moiety and to evaluate their cytotoxicity profile through hemolytic study. The synthetic methodology involved the reaction of 1, 4-benzodioxane-6-amine (1) with methanesulfonyl chloride (2) in aqueous alkaline medium under stirring for 2-3 hours and dynamic pH control at 9 to form N-(2, 3-dihydrobenzo[1, 4]dioxin-6-yl)methanesulfonamide (3). The synthesized sulfonamide, 3, was dissolved in DMF and LiH was added as an activator. Then, it was stirred for 2-3 hours with a series of aralkyl/alkyl halides, 4a-g, to yield N-alkyl/ aralkyl-N-(2, 3-dihydrobenzo[1, 4]dioxin-6- yl)methanesulfonamides (5a-g). The structural analysis of the derivatives was performed by FT-IR, 1H-NMR and EI-MS. When these molecules were evaluated for their hemolytic study, the molecule 5g was found to be least toxic amongst the series. Hence, this molecule might be utilized as safe therapeutic agent.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.HPLC of Formula: C8H9NO2, you can also check out more blogs about22013-33-8
Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem