Downstream synthetic route of 2879-20-1

As the paragraph descriping shows that 2879-20-1 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2879-20-1,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,as a common compound, the synthetic route is as follows.,2879-20-1

General procedure: A mixture of acetophenone 1a(0.5 mmol), acetonitrile 2 (7.5 mmol), and I2 (0.75 mmol) in DMSO (2mL) was stirred at 110 C. After disappearance of the reactant (monitored by TLC), added 50 mL water to the mixture, then extracted with EtOAc 3 times. The extract was washed with Na2S2O3 solution, dried over anhydrous Na2SO4 and evaporation. The residue was puriedby column chromatography to afford 3a.

As the paragraph descriping shows that 2879-20-1 is playing an increasingly important role.

Reference£º
Article; Gao, Qinghe; Liu, Shan; Wu, Xia; Wu, Anxin; Tetrahedron Letters; vol. 55; 47; (2014); p. 6403 – 6406;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem