Downstream synthetic route of 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxime

31127-39-6, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,31127-39-6 ,2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxime, other downstream synthetic routes, hurry up and to see

As a common heterocyclic compound, it belongs to benzodioxans compound, name is 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxime, and cas is 31127-39-6, its synthesis route is as follows.

General procedure: From exo-glucal 3A. An aqueous solution of NaOCl (5 mL, 9Chl prepared from a 36Chl commercial solution, diluted 4 times) was added slowly with a syringe pump (~16 h) at rt to a solution of methylene exo-glycal 3A (100 mg, 0.29 mmol) and aldoxime (0.58 mmol, 2 eq) in THF (10 mL). The mixture was diluted withwater (10 mL) and extracted with CH2Cl2 (3 20 mL). The organic layer was dried over MgSO4 and concentrated in vacuo. The crude product was purified by silica gel chromatography (petroleum ether/EtOAc, 7:3) to afford the corresponding spiro-isoxazolines 4a,f-j,l-p.

31127-39-6, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,31127-39-6 ,2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxime, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Goyard, David; Konya, Balint; Chajistamatiou, Aikaterini S.; Chrysina, Evangelia D.; Leroy, Jeremy; Balzarin, Sophie; Tournier, Michel; Tousch, Didier; Petit, Pierre; Duret, Cedric; Maurel, Patrick; Somsak, Laszlo; Docsa, Tibor; Gergely, Pal; Praly, Jean-Pierre; Azay-Milhau, Jacqueline; Vidal, Sebastien; European Journal of Medicinal Chemistry; vol. 108; (2016); p. 444 – 454;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem