Downstream synthetic route of 2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid

With the synthetic route has been constantly updated, we look forward to future research findings about 2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid,belong benzodioxans compound

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO431,mainly used in chemical industry, its synthesis route is as follows.,4442-53-9

A 20-mL round bottom flask was charged with 2,3-dihydrobenzo[b][l,4]dioxine- 5-carboxy-lic acid (1.8 g, 1.0 mmol), bromine (3.16 g, 2.0 mmol), and acetic acid (2 mL). The reaction mixture was stirred at 120¡ãC for 2 h and then cooled to 15¡ãC. It was filtered and the solid was washed with acetic acid to afford the title compound as a white solid (3.0 g, 60percent). LCMS: ESI (3 minute run), m/z = 337 [M+l]+; Retention time: 1.21 minute.

With the synthetic route has been constantly updated, we look forward to future research findings about 2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid,belong benzodioxans compound

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; BAKER-GLENN, Charles; BURDICK, Daniel Jon; CHAMBERS, Mark; CHAN, Bryan K.; CHEN, Huifen; ESTRADA, Anthony; GUNZNER-TOSTE, Janet; SHORE, Daniel; SWEENEY, Zachary; WANG, Shumei; ZHAO, Guiling; WO2013/79494; (2013); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem