With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20197-75-5,Methyl 1,4-Benzodioxan-6-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of methyl 2,3-dihydrobenzo[6][l,4]dioxine-6-carboxylate (780 mg, 4.0 mmol) in acetic acid (3 mL) was added dropwise cone. HNO3 (4 mL) while keeping the temperature below 20 0 C and the resulting reaction mixture was warmed to room temperature. After stirring for 1 hr, the mixture was poured onto ice- water with vigorous stirring. The resulting white precipitate was collected by vacuum filtration and dried under reduced pressure to yield methyl 7-nitro-2,3-dihydrobenzo[6][l,4]dioxine-6- carboxylate (889 mg, 92percent). 1H NMR (DMSO-d6, 600 MHz) delta 7.64 (s, IH), 7.30 (s, IH), 4.41-4.38 (m, 4H), 3.80 (s, 3H); MS (ES+) m/z 240. 0 (M+H)+.
As the paragraph descriping shows that 20197-75-5 is playing an increasingly important role.
Reference£º
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; WO2009/151561; (2009); A2;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem