As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO411,mainly used in chemical industry, its synthesis route is as follows.,2879-20-1
General procedure: A sealed tube was charged with acetophenone 5a (600 mg, 5 mmol), ethyl 3-oxo-3-(3,4,5-trimethoxyphenyl)propanoate 6a (1410 mg, 5.0 mmol), iodine (1396 mg, 5.5 mmol) and CuO (440 mg, 5.5 mmol) at room temperature, and then solvent DMSO (10 mL) was added. The resulting mixture was stirred at 70 C for 12 h, after disappearance of the reactant (monitored by TLC), and added 50 mL water to the mixture, then extracted with EtOAc 3 times (3 ¡Á 50 mL). The extract was washed with 10% Na2S2O3 solution, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (petroleum ether/EtOAc) to yield the desired product 1a as a yellow solid (yield: 84%).
With the synthetic route has been constantly updated, we look forward to future research findings about 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,belong benzodioxans compound
Reference£º
Article; Zhu, Yan-Ping; Cai, Qun; Jia, Feng-Cheng; Liu, Mei-Cai; Gao, Qing-He; Meng, Xiang-Gao; Wu, An-Xin; Tetrahedron; vol. 70; 50; (2014); p. 9536 – 9544;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem