Electric Literature of 20632-12-6, New Advances in Chemical Research, May 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In a document type is Article, and a compound is mentioned, 20632-12-6, Name is 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)propan-1-one, introducing its new discovery.
Excessive calpain activations contribute to serious cellular damage and have been found in many pathological conditions. Novel chromone carboxamides derived from ketoamides were prepared and evaluated for mu-calpain inhibition. Among synthesized, compound 2i was the most potent calpain inhibitor with an IC50 value of 0.24 ± 0.11 muM comparable to the activity of peptide aldehyde calpain inhibitor MDL 28,170. Furthermore, compound 2i showed higher selectivity for mu-calpain over two related cysteine proteases cathepsin B and cathepsin L, suggesting the chromone ring as a good scaffold for selective mu-calpain inhibitors.
I am very proud of our efforts over the past few months and hope to 20632-12-6 help many people in the next few years. Electric Literature of 20632-12-6