An article Modular Synthesis of Di- and Trisubstituted Imidazoles from Ketones and Aldehydes: A Route to Kinase Inhibitors WOS:000494562600088 published article about PRACTICAL SYNTHESIS; ORGANIC-SYNTHESIS; PROTEIN-KINASE; POTENT; LOK; 2,4(5)-DIARYL-1H-IMIDAZOLES; 2,4(5)-DIARYLIMIDAZOLES; 4(5)-ARYL-1H-IMIDAZOLES; ARYLATION in [de Toledo, Ian; Grigolo, Thiago; Pilli, Ronaldo A.] Univ Estadual Campinas, Inst Chem, Dept Organ Chem, UNICAMP, BR-13083970 Campinas, SP, Brazil; [Bennett, James M.; Elkins, Jonathan M.] Univ Oxford, Nuffield Dept Med, Struct Genom Consortium, Old Rd Campus Res Bldg,Roosevelt Dr, Oxford OX3 7DQ, England; [Elkins, Jonathan M.] Univ Estadual Campinas, Dept Genet & Evolucao, Inst Biol, Struct Genom Consortium, BR-13083886 Campinas, SP, Brazil in 2019.0, Cited 40.0. Recommanded Product: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6
A one-pot and modular approach to the synthesis of 2,4(5)-disubstituted imidazoles was developed based on ketone oxidation, employing catalytic HBr and DMSO, followed by imidazole condensation with aldehydes. This methodology afforded twenty-nine disubstituted NH-imidazoles (23%-85% yield). A three-step synthesis of 20 kinase inhibitors was achieved by employing this oxidation- condensation protocol, followed by bromination and Suzuki coupling in the imidazole ring to yield trisubstituted NH-imidazoles (23%-69%, three steps). This approach was also employed in the synthesis of known inhibitor GSK3037619A.
Recommanded Product: 1-(4-Nitrophenyl)ethanone. Welcome to talk about 100-19-6, If you have any questions, you can contact de Toledo, I; Grigolo, T; Bennett, JM; Elkins, JM; Pilli, RA or send Email.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem