An article Regio- and stereoselective synthesis of spiropyrrolidine-oxindole and bis-spiropyrrolizidine-oxindole grafted macrocycles through [3+2] cycloaddition of azomethine ylides WOS:000520511800053 published article about INTRAMOLECULAR 1,3-DIPOLAR CYCLOADDITION; SPIROOXINDOLE NATURAL-PRODUCTS; PROTEIN-PROTEIN INTERACTIONS; SCHIFF-BASE MACROCYCLES; CHIRAL SOLVATING AGENTS; DRUG DISCOVERY; ENCAPSULATION; INDOLIZIDINE; RECOGNITION; CAVITANDS in [Prabhakaran, Perumal; Rajakumar, Perumal] Univ Madras, Dept Organ Chem, Guindy Campus, Chennai 600025, Tamil Nadu, India in 2020.0, Cited 143.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Application In Synthesis of 1-(4-Nitrophenyl)ethanone
A convenient and efficient method for the regioselective macrocyclization of triazole bridged spiropyrrolidine-oxindole, and bis-spiropyrrolizidine-oxindole derivatives was accomplished through intra and self-intermolecular [3 + 2] cycloaddition of azomethine ylides. The chalcone isatin precursors 9a-i required for the click reaction were obtained from the reaction of N-alkylazidoisatin 4 and propargyloxy chalcone 8a-i which in turn were obtained by the aldol condensation of propargyloxy salicylaldehyde 6 and substituted methyl ketones 7a-i. The regio- and stereochemical outcome of the cycloadducts were assigned based on 2D NMR and confirmed by single crystal XRD analysis. High efficiency, mild reaction conditions, high regio- and stereoselectivity, atom economy and operational simplicity are the exemplary advantages of the employed macrocyclization procedure.
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Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem