Authors Joshi, SD; Kumar, SRP; Patil, S; Vijayakumar, M; Kulkarni, VH; Nadagouda, MN; Badiger, AM; Lherbet, C; Aminabhavi, TM in SPRINGER BIRKHAUSER published article about ENOYL-ACP REDUCTASE; BIOLOGICAL EVALUATION; TRIAZOLE DERIVATIVES; GALAHAD; AGENTS; DOCKING; DESIGN; BM212 in [Joshi, Shrinivas D.; Kumar, S. R. Prem; Patil, Sonali; Vijayakumar, M.; Kulkarni, Venkatarao H.; Nadagouda, Mallikarjuna N.; Aminabhavi, Tejraj M.] SETs Coll Pharm, Dept Pharmaceut Chem, Novel Drug Design & Discovery Lab, Dharwad, Karnataka, India; [Badiger, Aravind M.] BDR Pharmaceut, Baroda, Gujarat, India; [Lherbet, Christian] Univ Toulouse, Lab Synth Physicochim Mol Interet Biol, LSPCMIB, UPS, 118 Roote Narbonne, F-31062 Toulouse 9, France in 2019.0, Cited 40.0. COA of Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6
Substituted phenylthiazolyl benzamide and pyrrolyl benzamide derivatives were developed using molecular hybridization technique to create novel lead antimycobacterial molecules used to fight against Mycobacteriumtuberculosis. The newly synthesized molecules have inhibited InhA, the enoyl-ACP reductase enzyme from the mycobacterial type II fatty acid biosynthetic pathway. Of these, compound 3b showed H-bonding interactions with Tyr158 and co-factor NAD(+) that binds the active site of InhA. All the molecules were screened for in vitro antitubercular activity against M. tuberculosis H(37)Rv, as well as some representative molecules as the inhibitors of InhA. Thirteen compounds exhibited good anti-TB activities (MIC = 1.6 mu g/mL), but only few representative molecules showed the moderate InhA enzyme inhibition activity. Basic core moiety and docked mode of all the synthesized compounds inside the proposed binding pocket of InhA with the final selected pharmacophore model molecular alignment for InhA receptor ligands. [GRAPHICS] .
About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Joshi, SD; Kumar, SRP; Patil, S; Vijayakumar, M; Kulkarni, VH; Nadagouda, MN; Badiger, AM; Lherbet, C; Aminabhavi, TM or concate me.. COA of Formula: C8H7NO3
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem