Category: benzodioxans. Sun, LP; Wang, PP; Xu, LL; Gao, LX; Li, J; Piao, HR in [Sun, Liangpeng] Yanbian Univ, Coll Med, Yanji 133000, Peoples R China; [Wang, Peipei; Gao, Lixin; Li, Jia] Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China; [Xu, Lili; Piao, Huri] Yanbian Univ, Key Lab Nat Resources Changbai Mt & Funct Mol, Minist Educ, Coll Pharm, Yanji 133000, Peoples R China published Discovery of 1,3-diphenyl-1H-pyrazole derivatives containing rhodanine-3-alkanoic acid groups as potential PTP1B inhibitors in 2019.0, Cited 29.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.
Two series of 1,3-diphenyl-1H-pyrazole derivatives containing rhodanine-3-alkanoic acid groups were identified as competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors. Among the compounds studied, IIIv was found to have the best in vitro inhibition activity against PTP1B (IC50 = 0.67 +/- 0.09 mu M) and the best selectivity (9-fold) between PTP1B and T-cell protein tyrosine phosphatase (TCPTP). Molecular docking studies demonstrated that compounds IIIm, IIIv and IVg could occupy simultaneously at both the catalytic site and the adjacent pTyr binding site. These results provide novel lead compounds for the design of inhibitors of PTP1B as well as other PTPs.
Category: benzodioxans. Welcome to talk about 100-19-6, If you have any questions, you can contact Sun, LP; Wang, PP; Xu, LL; Gao, LX; Li, J; Piao, HR or send Email.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem