An article Novel thiazole-pyrazolone hybrids as potent ACE inhibitors and their cardioprotective effect on isoproterenol-induced myocardial infarction WOS:000562248800001 published article about ANGIOTENSIN-CONVERTING-ENZYME; BIOLOGICAL EVALUATION; ANTIFUNGAL ACTIVITY; OXIDATIVE STRESS; ANTIBACTERIAL; DERIVATIVES; ANTICANCER; DISEASE; DESIGN; SERIES in [You, Hongwen] Shandong First Med Univ, Dept Cardiol, Shandong Prov Hosp, Jinan, Shandong, Peoples R China; [Su, Xinyou] Shandong Univ, Jinan Cent Hosp, Cheeloo Coll Med, Dept Oncol, Jinan, Shandong, Peoples R China; [Su, Guoying] Shandong Univ, Jinan Cent Hosp, Cheeloo Coll Med, Dept Cardiol, Jinan 250013, Shandong, Peoples R China in 2020.0, Cited 39.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Quality Control of 1-(4-Nitrophenyl)ethanone
A facile synthesis of a group of novel thiazole-pyrazolone hybrids and their investigation for angiotensin-converting enzyme (ACE) inhibition are reported in this study. These compounds were synthesized using a well-known approach, based on the condensation of ethyl acetoacetate with thiazolylhydrazines, and characterized by various spectroscopic and analytical techniques. The entire set of compounds displayed a moderate-to-excellent inhibitory activity against ACE. In particular, compound4iwas found to be the most potent ACE inhibitor and was further studied for cardioprotective effects against isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Compound4iimproved the cardiac function and prevented cardiac injury induced by ISO in Sprague Dawley rats. The levels of oxidative stress and proinflammatory cytokines were also restored to near normal by4ias compared with the ISO group. In the Western blot analysis, compound4iprevented mitochondrial apoptosis after MI by downregulating the expression of cleaved caspase-3 and Bax, with the upregulation of Bcl-2, as compared with the ISO group.
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Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem