Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2160535-56-6, is researched, SMILESS is CC([S@](N[C@@H](C1=CC=CC(C2(C)C)=C1OC3=C2C=CC=C3P(C4=CC=CC=C4)C5=CC=CC=C5)C6=CC=C(OC)C=C6)=O)(C)C, Molecular C39H40NO3PSJournal, Article, Research Support, Non-U.S. Gov’t, Angewandte Chemie, International Edition called Gold-Catalyzed Asymmetric Intramolecular Cyclization of N-Allenamides for the Synthesis of Chiral Tetrahydrocarbolines, Author is Wang, Yidong; Zhang, Peichao; Di, Xiaoyu; Dai, Qiang; Zhang, Zhan-Ming; Zhang, Junliang, the main research direction is gold catalyzed asym intramol cyclization allenamide chiral hydrocarboline synthesis; chiral sulfinamide phosphine ligand gold catalyzed asym intramol cyclization; desbromoarborescidine A synthesis desbromoarborescidine C formal synthesis; deplancheine formal synthesis; desymmetrization allenamide; allenamides; cyclization; enantioselectivity; gold; tetrahydrocarboline.Category: benzodioxans.
Highly enantioselective gold-catalyzed intramol. cyclization of N-allenamides was implemented by utilizing a designed chiral sulfinamide phosphine ligand (PC-Phos) [e.g., allenamide I → tetrahydrocarboline II (99%, 96% ee) in presence of Me2S.AuCl, AgNTf2 and ligand III in CH2Cl2 at -50°]. This represents the first example of highly enantioselective intramol. cyclization of N-allenamides. The practicality of this reaction was validated in the total synthesis of (R)-desbromoarborescidine A and formal synthesis of (R)-desbromoarborescidine C and (R)-deplancheine. Moreover, the catalyst system PC-Phos/AuNTf2 proved to be specifically efficient to promote the desymmetrization of N-allenamides in excellent yields with satisfactory ee values.
Compounds in my other articles are similar to this one((R)-N-((R)-(5-(Diphenylphosphanyl)-9,9-dimethyl-9H-xanthen-4-yl)(4-methoxyphenyl)methyl)-2-methylpropane-2-sulfinamide)Category: benzodioxans, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.