Category: 4442-54-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4442-54-0,2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: A mixture of compound 9 or 10 (0.11 mmol), O-(7-aza-1H-benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (0.21mmol), and N,N-diisopropylethylamine (0.54 mmol) in dry DMF (1.5 mL) was stirred at 0 ¡ãC for 30 min. The appropriate acid (0.16 mmol) was then added. After stirring at room temperature for 1-4 h, the reaction mixture was diluted with saturated aqueous NaHCO3, and extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous MgSO4, and concentrated in vacuo. The residue was purified by column chromatography on silica gel eluting with EtOAc-hexane (1:1 to 1:3) to afford the corresponding compounds 11a-o and 12a-c.

4442-54-0, The synthetic route of 4442-54-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Koh, Eun Jeong; El-Gamal, Mohammed I.; Oh, Chang-Hyun; Lee, So Ha; Sim, Taebo; Kim, Garam; Choi, Hong Seok; Hong, Jun Hee; Lee, Sang-Gi; Yoo, Kyung Ho; European Journal of Medicinal Chemistry; vol. 70; (2013); p. 10 – 21;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

4442-54-0, 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid (1 mmol) with concentrated sulfuric acid (0.5 mL) in methanol(30 mL) was heated at 65¡ãC overnight. The solvent was removed in vacuo, the oil was dissolved in ethyl acetate (20 mL) and extracted with water (40 mL). After drying the organic layer with anhydrous Na2SO4and evaporating the solvent under reduced pressure asolid precipitate was formed. It was recrystallized fromethanol., 4442-54-0

4442-54-0 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid 2758833, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Article; Wang; Liu; Xu; Sun; Russian Journal of General Chemistry; vol. 87; 11; (2017); p. 2671 – 2677; Zh. Obshch. Khim.; vol. 87; 11; (2017); p. 2671 – 2677,7;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

4442-54-0, 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid (20 mg, 0.11 mmol), Example 13 Part E compound (20 mg, 0.083 mmol), HOAt (20 mg, 0.147 mmol), EDCl (40 mg, 0.21 mmol), and DIPEA (40mg, 0.31 mmol) in DMF (1 mL) was stirred at 25¡ã C. for 18 h. The reaction mixture was concentrated in vacuo, and the residue was purified by preparative HPLC (Phenomenex AXIA 5u C18 30.x.100 mm column; detection at 220 nm; flow rate=40 mL/min; continuous gradient from 30percent A to 100percent B over 10 min+1 min hold time at 100percent B, where A=90:10:0.1 H2O:MeOH:TFA and B=90:10:0.1 MeOH:H2O:TFA) to give the title compound (8.2 mg, 24percent yield) as a white solid. [M+H]+=413.3; 1H NMR (400 MHz, CDCl3) delta 1.29 (t, J=7.03 Hz, 6 H), 3.27-3.36 (d, J=21.09 Hz, 2 H), 4.06-4.16 (m, 4 H), 4.28-4.37 (m, 4 H), 6.94 (d, J=3.52 Hz, 1 H), 6.99 (d, J=8.35 Hz, 1 H), 7.64-7.71 (m, 2 H).

4442-54-0, The synthetic route of 4442-54-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bristol-Myers Squibb Company; US2008/9465; (2008); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

4442-54-0, 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 2,3-Dihydrobenzo[b]-[1,4] dioxinecarboxylic acid A, B and C (10 mmol) in ethanol (200 mL) was treated with thionyl chloride (5 mL) under reflux overnight. Excess ethanol was distilled out and the solid left was dissolved in ethyl acetate (150 mL), washed with saturation sodium bicarbonate (200 mL) and then sodium chloride (200 mL). After drying the organic layer with anhydrous Na2SO4 and evaporating the solvent under reduced pressure and solid appeared. The solid was recrystallized from ethanol to obtain the compound A1, B1 and C1. The completion of the reaction was monitored on TLC by using silica gel-G coated plates by using ethyl acetate and petroleum ether (1 : 1) as the elution and observed in UV light.

4442-54-0, 4442-54-0 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid 2758833, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Article; Song, Xiaoda; Yang, Yushun; Zhao, Jing; Chen, Yangjian; Chemical and Pharmaceutical Bulletin; vol. 62; 11; (2014); p. 1110 – 1118;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4442-54-0,2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: Method I Ba (1 mmol) and 2,3-dihydrobenzo[b][1,4]dioxin-6-carboxylic acid (or 2,3-dihydrobenzo[b][1,4]dioxin-2-carboxylic acid) (1 mmol) together with EDCI (1.5 mmol) and HOBt (0.05 mmol) in CH2Cl2 (20 mL) were refluxed at room temperature for 10 h. While the reaction completed, the solution was washed with water for three times (30 mL each time). The remaining water layer was extracted by EtOAc for three times (30 mL each time). The organic layers (CH2Cl2 and EtOAc) were combined and then evaporated. The separated solid was crystallized from mixture of DMF and ethanol (9:1) to obtain the corresponding compound as translucent solid. White crystal, mp: 120-121 ¡ãC. 1H NMR (CDCl3, 300 MHz) delta: 3.15-3.23 (d, J = 17.7 Hz, 1H), 3.69-3.79 (m, 1H), 4.31-4.32 (t, J = 2.4 Hz, 4H), 5.79-5.85 (m, 1H), 6.90-6.93 (d, J = 8.4 Hz, 1H), 7.27-7.37 (m, 5H), 7.43-7.44 (m, 3H), 7.65-7.68 (d, J = 8.1 Hz, 2H), 7.73-7.75 (m, 2H). MS (ESI): 385.15 (C24H21N2O3, [M+H]+). Anal. Calcd for C24H20N2O3: C, 74.98; H, 5.24; N, 7.29; O, 12.49. Found: C, 74.59; H, 5.23; N, 7.30.

4442-54-0, 4442-54-0 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid 2758833, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Article; Yang, Yu-Shun; Li, Qing-Shan; Sun, Shuai; Zhang, Yan-Bin; Wang, Xiao-Liang; Zhang, Fei; Tang, Jian-Feng; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 20; 20; (2012); p. 6048 – 6058;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid, cas is 4442-54-0, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.,4442-54-0

[00339] Compound 243, N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-iodophenyl)-2-methylquinoline-6-carboxamideOxalyl chloride (0.08 mL, 0.909 mmol) was added dropwise to a solution of 2- methylquionline-6-carboxylic acid (170 mg, 0.909 mmol) and DMF (1 .466 muIota_, 0.019 mmol) in dry DCM (2.3 mL). The reaction mixture was stirred for 30 minutes, then concentrated in vacuo, dissolved in DCM (5 mL) and concentrated in vacuo. The concentrate was dissolved in DCM (5 mL) and added drop wise to a stirred solution of pyridine (0.122 mL) and A/-(3-amino-4-iodophenyl)-2,3-dihydrobenzo[b][1 ,4]dioxine-6- carboxamide (300 mg, 0.757 mmol) in DCM (2.3 mL). After stirring for 16 hours, the reaction mixture was concentrated in vacuo. The concentrate was suspended in MeOH (10 mL) and diluted with water (60 mL). The solid was filtered, washed with water and dried on the high vac to afford the desired product as a pale yellow solid (351 mg, 82percent). 1H-NMR (500 MHz, DMSO): delta 10.29 (s, 1 H), 10.24 (s, 1 H), 8.63 (d, J = 2.0 Hz, 1 H), 8.45 – 8.39 (m, 1 H), 8.26 (dd, J = 8.8, 2.1 Hz, 1 H), 8.05 (d, J = 8.8 Hz, 1 H), 8.01 (d, J = 2.5 Hz, 1 H), 7.88 (d, J = 8.7 Hz, 1 H), 7.63 – 7.49 (m, 4H), 4.39 – 4.26 (m, 5H), 2.71 (s, 3H). HRMS (ESI+): Found [M+H]+566.0533 C26H21IN3O4 requires 566.0571 .

With the rapid development of chemical substances, we look forward to future research findings about 4442-54-0

Reference£º
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; JONES, Keith; RYE, Carl; CHESSUM, Nicola; CHEESEMAN, Matthew; PASQUA, Adele Elisa; PIKE, Kurt Gordon; FAULDER, Paul Frank; WO2015/49535; (2015); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4442-54-0,2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid,as a common compound, the synthetic route is as follows.

A mixture of 2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid (1 mmol) with concentrated sulfuric acid (0.5 mL) in methanol(30 mL) was heated at 65¡ãC overnight. The solvent was removed in vacuo, the oil was dissolved in ethyl acetate (20 mL) and extracted with water (40 mL). After drying the organic layer with anhydrous Na2SO4and evaporating the solvent under reduced pressure asolid precipitate was formed. It was recrystallized fromethanol., 4442-54-0

4442-54-0 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid 2758833, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Article; Wang; Liu; Xu; Sun; Russian Journal of General Chemistry; vol. 87; 11; (2017); p. 2671 – 2677; Zh. Obshch. Khim.; vol. 87; 11; (2017); p. 2671 – 2677,7;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

4442-54-0, 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of Compound 122, N-(3-Nitrophenyl)-2,3-dihydro-1,4-benzodioxine-7-carboxamide[00148] 2,3-Dihydrobenzo[b][1,4]dioxine-6-carboxylic acid (3.13 g, 17.38 mmol) was dissoved in DMA (25 mL) and (7.57 ml_, 43.44 mmol) and HATU (6.61 g, 17.38 mmol) added under an inert atmosphere. The reaction was allowed to stir for 15 minutes then 3-nitroaniline (2.0 g, 14.48 mmol) was added and the reaction stirred at ambient temperature overnight. The reaction was heated for a further 16 hours at 40 ¡ãC then concentrated in vacuo and water added. The solids were isolated by filtration, washed with wate and dried in a vacuum oven. The solids were stirred in EtOAc for an hour and then filtered. The filtrate was evaporated down and the solids were triturated with DCM then filtered. The collected solids were combined to afford the desired material as a cream solid (3.44 g, 79percent).1H NMR (400 MHz, DMSO, 30¡ãC) d 4.33 (4H, tq), 7.03 (1 H, d), 7.53 – 7.59 (2H, m), 7.65 (1 H, t), 7.95 (1 H, ddd), 8.20 (1 H, ddd), 8.78 – 8.82 (1 H, m), 10.48 (1 H, s). m/z (ES+) (M+H)+ = 301 ., 4442-54-0

4442-54-0 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid 2758833, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; JONES, Keith; RYE, Carl; CHESSUM, Nicola; CHEESEMAN, Matthew; PASQUA, Adele Elisa; PIKE, Kurt Gordon; FAULDER, Paul Frank; WO2015/49535; (2015); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid, cas is 4442-54-0, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.,4442-54-0

5.0mmol of acetophenone and 5lmmol benzaldehyde into the 50ml round bottom burning, adding 20ml of anhydrous ethanol, magnetic stirring lOmin to mix evenly, slowly dropping 40percent NaOH solution 10ml, magnetic stirring, room temperature reaction 2h TLC). The product was precipitated as a solid, filtered and washed with a large amount of distilled water. The solid was washed three times with cold ethanol (3 ml each) and dried. The product was mixed with ethanol and acetone (volume ratio: Acetone = 10: 1). The compound obtained above was added to a 50 ml flask and heated to 80 ¡ã C in 20 ml of isopropanol (or 20 ml of ethanol). To the solution was added dropwise 2 mmol of hydrazine hydrate 80, The reaction was stirred at 80 ¡ã C for 5 h (TLC). After the end of the reaction, the distillation was carried out under reduced pressure until all of the ethanol was distilled off. The product was precipitated in a large amount as a solid, filtered and washed three times with cold ethanol (each about 3 ml). Within 20 min, 1.0 mmol of the obtained product, 1,4-benzodioxan-6-carboxylic acid was dissolved in 20 ml of methylene chloride at room temperature. 1.5 mmol of EDCI and 0.05 mmol of HOBt were added and the reaction was stirred for 10 h (TLC). After the completion of the reaction, the reaction solution was washed three times with 50 ml of water (150 ml each), and the resulting aqueous phase was combined three times, and extracted twice with 210 ml of ethyl acetate (70 ml each). The organic phase (dichloromethane and ethyl acetate) And distilled to dryness under reduced pressure to give a solid product which was recrystallized from a mixture of ethanol and acetone (volume ratio of ethanol: acetone = 10: 1) to give the title compound (white crystals).

With the rapid development of chemical substances, we look forward to future research findings about 4442-54-0

Reference£º
Patent; Nanjing University; Zhu, Hai Liang; Yang, yushun; Ding, Shu Ting; Zhang, Fei; Zhang, Yan Bin; Wang, Xiao Liang; Tang, Jian Feng; (22 pag.)CN103304546; (2016); B;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4442-54-0,2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid,as a common compound, the synthetic route is as follows.

Method I Ba (1 mmol) and 2,3-dihydrobenzo[b][1,4]dioxin-6-carboxylic acid (or 2,3-dihydrobenzo[b][1,4]dioxin-2-carboxylic acid) (1 mmol) together with EDCI (1.5 mmol) and HOBt (0.05 mmol) in CH2Cl2 (20 mL) were refluxed at room temperature for 10 h. While the reaction completed, the solution was washed with water for three times (30 mL each time). The remaining water layer was extracted by EtOAc for three times (30 mL each time). The organic layers (CH2Cl2 and EtOAc) were combined and then evaporated. The separated solid was crystallized from mixture of DMF and ethanol (9:1) to obtain the corresponding compound as translucent solid. 4.5.4 (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)methanone (C4) White crystal, mp: 123-124 ¡ãC. 1H NMR (CDCl3, 300 MHz) delta: 3.15-3.22 (d, J = 17.1 Hz, 1H), 3.72-3.78 (m, 1H), 3.81 (s, 3H), 4.31-4.32 (t, J = 2.4 Hz, 4H), 5.75-5.80 (m, 1H), 6.85-6.92 (m, 3H), 7.24-7.26 (m, 2H), 7.42-7.44 (m, 3H), 7.64-7.66 (d, J = 7.8 Hz, 2H), 7.73-7.76 (m, 2H). MS (ESI): 415.16 (C25H23N2O4, [M+H]+). Anal. Calcd for C25H22N2O4: C, 72.45; H, 5.35; N, 6.76; O, 15.44. Found: C, 72.21; H, 5.34; N, 6.76.

4442-54-0, 4442-54-0 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid 2758833, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Article; Yang, Yu-Shun; Li, Qing-Shan; Sun, Shuai; Zhang, Yan-Bin; Wang, Xiao-Liang; Zhang, Fei; Tang, Jian-Feng; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 20; 20; (2012); p. 6048 – 6058;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem