Category: 39270-39-8

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A cyclometalated rhodium complex has been shown to perform highly selective and efficient reduction of aldehydes, deriving the hydrogen from methanol. With methanol as both the solvent and hydrogen donor under mild conditions and an open atmosphere, a wide range of aromatic aldehydes were reduced to the corresponding alcohols, without affecting other functional groups.

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Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Reference of 39270-39-8, With the volume and accessibility of scientific research increasing across the world, it has never been more important to continue building the reputation for quality and ethical publishing we’ve spent the past two centuries establishing. Type is Patent, and a compound is mentioned, 39270-39-8, Name is (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanol, introducing its new discovery.

Compounds of formula (I’) wherein A, R1, R2, T1, T2, T3, T4, L, W, Z, R”’, m and n have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer’s disease.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 39270-39-8. This is the end of this tutorial post, and I hope it has helped your research about 39270-39-8

Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Safety of (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanol, You could be based in a university, combining chemical research with teaching; or in a public-sector research center, helping to ensure national healthcare provision keeps pace with new discoveries. In a document type is Article, and a compound is mentioned, 39270-39-8, Name is (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanol, introducing its new discovery.

All-carbon quaternary centers are prevalent in bioactive small molecules. However, their efficient construction remains a formidable synthetic challenge. Here we report cyclic iodine(III) reagents enable the synthesis of cyclopentanones, cyclohexanones, and dihydrofuranones bearing alpha-quaternary centers by photoredox catalysis. The reaction proceeds by the formation of the novel cyclic iodine(III) reagent-allylic alcohol complex, which enables the first alkyl boronate addition and semi-pinacol rearrangement of allylic alcohols with dual alcohol and olefin activation. The reaction is suitable for gram scale synthesis and is transformable to alcohols, olefins, oximes, and lactones with an alpha-quaternary center in one step.

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 39270-39-8 Safety of (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanol

Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

New research progress on 39270-39-8 in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. category: benzodioxans, In a article, mentioned the application of 39270-39-8, Name is (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanol, molecular formula is C9H10O3

Esters can be successfully reduced to the corresponding alcohols with potassium borohydride/lithium chloride under microwave irradiation without solvent. The reactions are generally completed in 2-8 minutes, with the yields varying from 55% to 95%.

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Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

SDS of cas: 39270-39-8, Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 39270-39-8, Name is (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanol,introducing its new discovery.

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

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Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, improving understanding of environmental issues, and development of new chemical products and materials. Quality Control of (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanol, In a article, mentioned the application of 39270-39-8, Name is (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanol, molecular formula is C9H10O3

1-((2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-4-substituted-phenylpiperazine moiety was prepared and has been found to be a new and selective ligand for the enzyme cyclooxygenase-2 (COX-2). The biological activity of compound 3k as anti-inflammatory agent was further investigated both in vitro and in vivo. Notably, compound 3k exhibited the best anti-inflammatory activity among the eleven designed compounds with no toxicity, as determined by the ulcerogenic activity. Computational docking studies also showed that compound 3k has interaction with COX-2 key residues in the active site. Compound 3k maybe a new anti-inflammatory lead-candidate as powerful and novel non-ulcerogenic.

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Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or-COO-C1-C4-alkyl group; Y represents NH, N-C1-C10-alkyl, O, or S; Z represents NH, N-C1-C10-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N-C1-C10-alkyl, N-aryl, NSO2-C1-C10-alkyl, N-SO2-aryl, or N-SO2-heteroaryl; R1 to R8 each independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments.

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Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 39270-39-8,Synthetic Route of 39270-39-8, In a article, mentioned the application of 39270-39-8, molecular formula is C9H10O3

Reaction of 2′-benzylbenzohydrazides with concentrated polyphosphoric acid gave 2,5-diaryl-1,3,4-oxadiazoles and a polybenzyl.Cyclodehydration to phthalazines was not observed.It is inferred from product substitution patterns that CH2-N bond cleavage occurs with polybenzyls forming from the benzyl moiety and oxadiazoles from the benzohydrazide fragment.Other reported reactions which generate benzyl fragments lead to bibenzyl and are considered to involve trapping of the cleavage products within a solvent cage.The observed production of polybenzyls is therefore interpreted in terms of the formation of free benzyl fragments.A tetrahydrophthalazine derivative was produced from the addition of diethyl azodicarboxylate to the photodiene of o-methylbenzophenone, but this could not be converted into a phthalazine.

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Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Product Details of 39270-39-8, Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. In a document type is Patent, and a compound is mentioned, 39270-39-8, Name is (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanol, introducing its new discovery.

The present invention comprises glucosylceramide synthase (GCS) inhibitors of structural formula (I), and pharmaceutically acceptable salts thereof, wherein R1, E, A, L, X1, Q, R4, R5, m and n, are as defined herein, as well as N-oxides of them and pharmaceutically acceptable salts thereof. The invention further comprises composition comprising the compounds, N-oxides, and/or pharmaceutically acceptable salts thereof. The invention also comprises use of the compounds and compositions for treating diseases in which GCS is a mediator or is implicated. The invention also comprises use of the compounds in and for the manufacture of medicaments, particularly for treating diseases in which GCS is a mediator or is implicated.

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Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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A series of novel gemifloxacin (GMFX) derivatives containing a substituted benzyloxime moiety with remarkable improvement in lipophilicity were synthesized. The target compounds evaluated for their in vitro antibacterial activity against representative strains. Our results reveal that most of the target compounds have considerable potency against all of the tested Gram-positive strains including MRSA and MRSE (MIC: <0.008-8 mug/mL), although they are generally less active than the references against the Gram-negative strains. In particular, compound 11l (MIC: <0.008-4 mug/mL) was found to be 8-2048 and 2-128 times more potent than levofloxacin (LVFX) and GMFX against the Gram-positive strains, respectively. Moreover, against MRSA clinical isolates, 11l (MIC90: 1 mug/mL) is 8-fold more active than GMFX, and 2-fold more active than GMFX and moxifloxacin against MRSE clinical isolates (MIC90: 4 mug/mL). Crown Copyright Keep reading other articles of 39270-39-8! Don’t worry, you don’t need a PhD in chemistry to understand the explanations! Application In Synthesis of (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanol

Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem