Category: 3663-80-7

2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid, cas is 3663-80-7, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

Method I Ba (1 mmol) and 2,3-dihydrobenzo[b][1,4]dioxin-6-carboxylic acid (or 2,3-dihydrobenzo[b][1,4]dioxin-2-carboxylic acid) (1 mmol) together with EDCI (1.5 mmol) and HOBt (0.05 mmol) in CH2Cl2 (20 mL) were refluxed at room temperature for 10 h. While the reaction completed, the solution was washed with water for three times (30 mL each time). The remaining water layer was extracted by EtOAc for three times (30 mL each time). The organic layers (CH2Cl2 and EtOAc) were combined and then evaporated. The separated solid was crystallized from mixture of DMF and ethanol (9:1) to obtain the corresponding compound as translucent solid. 4.5.28 (2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)(5-(2-fluorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)methanone (D13) White crystal, mp: 189-190 ¡ãC. 1H NMR (CDCl3, 300 MHz) delta: 3.22-3.29 (m, 1H), 3.83-3.89 (m, 1H), 4.43-4.51 (m, 1H), 4.53-4.67 (m, 1H), 5.60-5.68 (m, 1H), 5.80-5.85 (m, 1H), 6.86-6.90 (m, 3H), 7.02-7.17 (m, 3H), 7.21-7.26 (m, 2H), 7.45-7.48 (m, 3H), 7.75-7.78 (d, J = 7.8 Hz, 2H). MS (ESI): 403.14 (C24H20FN2O3, [M+H]+). Anal. Calcd for C24H19FN2O3: C, 71.63; H, 4.76; F, 4.72; N, 6.96; O, 11.93. Found: C, 71.25; H, 4.73; N, 6.97., 3663-80-7

With the rapid development of chemical substances, we look forward to future research findings about 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid

Reference£º
Article; Yang, Yu-Shun; Li, Qing-Shan; Sun, Shuai; Zhang, Yan-Bin; Wang, Xiao-Liang; Zhang, Fei; Tang, Jian-Feng; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 20; 20; (2012); p. 6048 – 6058;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

3663-80-7, 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2, 3-dihydrobenzo[b][l,4]dioxine-2-carboxylic acid (1 equiv) and oxalyl dichloride (2 equiv) in dry DCM was added 4 drops dry DMF. After the mixture was stirred at room temperature for 4 h, the solvent was removed under reduced pressure to give 2,3-dihydrobenzo[b][l,4]dioxine-2- carbonyl chloride in quantity yield. The acid chloride (1.5 equiv) was then dissolved in DCM and was added to a solution of 2-amino-5-bromobenzo nitrile (1 equiv) and pyridine (3 equiv) in DCM at O 0C. The reaction mixture was allowed to stir at room temperature until the starting material disappeared as monitored by TLC. The reaction was quenched by addition of saturated aqueous NaHCCh and extracted with EtOAc (3 X). The EtOAc extracts were washed with brine and dried over sodium sulfate to give crude 1-1 which was then purified by chromatography over silica gel (92percent yield). 1H-NMR (DMSO-ddelta, 400 MHz) delta 10.4 (s, IH), 8.16 (s, IH), 7.92 (dd, J=8.8, 2.4 Hz, IH), 7.60 (d, J=8.8 Hz, IH), 7.04-7.01 (m, IH), 6.93-6.85 (m, 3H), 5.11 (dd, 7=6.0, 2.8 Hz, IH), 4.45 (dd, J=I 1.6, 2.8 Hz, IH), 4.36 (dd, J=I 1.6, 6.0 Hz, IH)., 3663-80-7

3663-80-7 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid 2735450, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Patent; FENG, Yangbo; LOGRASSO, Philip; BANNISTER, Thomas; SCHROETER, Thomas; FANG, Xingang; YIN, Yan; CHEN, Yen Ting; SESSIONS, Hampton; CHOWDHURY, Sarwat; LUO, Jun-Li; VOJKOVSKY, Tomas; WO2010/56758; (2010); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

3663-80-7, 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,3663-80-7

At 25 ¡ã C and N 2 atmosphere,Add 1,3-dicyclohexylcarbodiimide to a solution of 2,3-benzo[1,4]dioxin-2-carboxylic acid (12 mmol) and pyridine (20 mmol) in 20 mL of dry dichloromethane Amine DCC (15 mmol).After 5 minutes, 2-((1-amino-2-methylpropan-2-yl)amino)-1-(5-hydroxy-1H-pyrrole[3,2]pyridin-1-yl)B was added. ketone(10 mmol) and the mixture was stirred overnight.TLC (95:5 in dichloromethane: methanol containing 2percent ammonia) indicated that all of the starting material was consumed.The reaction was quenched with sodium bicarbonate and filtered through a pad of Celite.The plug was rinsed with dichloromethane and the aqueous layer was extracted with dichloromethane.After the combined organic layers are dried over Na 2 SO 4 ,Filtration and concentration in vacuo gave 3.6 g, m.The crude product was purified by flash chromatography.Use 2percent to 8percent MeOH:Purification by stepwise gradient of dichloromethane and 2percent ammonia,Obtained 3.2 g of white powder as N-(2-((2-(5-hydroxy-1H-pyrrole[3,2]pyridin-1-yl)-2-ethoxy)amino)-2-methylpropane Base)-(2,3-benzo[1,4]dioxin)-2-carboxamide,The yield was 85percent.

As the paragraph descriping shows that 3663-80-7 is playing an increasingly important role.

Reference£º
Patent; Sang Qi; (11 pag.)CN108164528; (2018); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid, cas is 3663-80-7, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

Benzo-dioxane-2-carboxylic acid was added, 100 ml of absolute ethanol was added, and 10 ml of concentrated sulfuric acid was added, and the mixture was refluxed at 80 ¡ã C overnight (TLC). After the completion of the reaction, the reaction mixture was distilled under reduced pressure to one-fifth of its original volume, and 40 ml of water was added thereto. The mixture was extracted three times with ethyl acetate, washed with saturated NaHC03 solution and saturated NaCl solution, dried over MgS04 and distilled under reduced pressure to give The resulting ester, 2. Ommol, was dissolved in 30 ml of absolute ethanol and 2. l mmol of hydrazine hydrate 80 was added and refluxed overnight (TLC). Acetophenone (5.0 mmol) and benzaldehyde (5.1 mmol) were dissolved in 20 ml of ethanol, followed by magnetic separation. The resulting mixture was stirred at room temperature for 2 hours. After the completion of the reaction, the reaction mixture was distilled under reduced pressure until ethanol was distilled off. Stirring 10min to make the mixture hook, slowly dropping 40percent Na0H solution 10ml, magnetic stirring, room temperature reaction 2h (TLC detection reaction progress), the product of solid precipitation. After filtration, the solid was washed with a large amount of distilled water and finally washed three times with cold ethanol (3 ml each time) and dried. The product was mixed with ethanol and acetone (volume ratio of ethanol: acetone = 1: 1) The resulting hydrazide was dissolved in 25 ml of absolute ethanol and dissolved in 80 ¡ã C. The reaction was stirred at 80 ¡ã C for 20 h (TLC detection). After the completion of the reaction, the ethanol was evaporated to dryness under reduced pressure. The resulting mixture was subjected to column chromatography, and the first substance (raw material chalcone) was discarded using a developing solvent having a volume ratio of petroleum ether to ethyl acetate = 10: The mixed solution containing the second substance (target product) was distilled under reduced pressure to distill off the whole of the solvent to obtain the target product as a crude product, which was recrystallized from a mixture of ethanol and acetone (volume ratio of ethanol: acetone = 10: 1) The product (white crystals), 3663-80-7

With the rapid development of chemical substances, we look forward to future research findings about 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid

Reference£º
Patent; Nanjing University; Zhu, Hai Liang; Yang, yushun; Ding, Shu Ting; Zhang, Fei; Zhang, Yan Bin; Wang, Xiao Liang; Tang, Jian Feng; (22 pag.)CN103304546; (2016); B;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

3663-80-7, 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,3663-80-7

General procedure: The dipeptides after appropriate deprotection and the amino acid methyl esters were coupled with 1,4-benzodioxane-2-carboxylic acid using DCC as acoupling reagent and TEA as a base in different reaction conditions like microwave, sonication, refluxing and conventional methods to give the desired products (2a-2e) (Scheme-2).

The synthetic route of 3663-80-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Malipeddi, Himaja; Gowda, Visruth; Das, Moonjit; Indian Journal of Heterocyclic Chemistry; vol. 25; 2; (2015); p. 113 – 118;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

A common heterocyclic compound, the benzodioxans compound, name is 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid,cas is 3663-80-7, mainly used in chemical industry, its synthesis route is as follows.

Method I Ba (1 mmol) and 2,3-dihydrobenzo[b][1,4]dioxin-6-carboxylic acid (or 2,3-dihydrobenzo[b][1,4]dioxin-2-carboxylic acid) (1 mmol) together with EDCI (1.5 mmol) and HOBt (0.05 mmol) in CH2Cl2 (20 mL) were refluxed at room temperature for 10 h. While the reaction completed, the solution was washed with water for three times (30 mL each time). The remaining water layer was extracted by EtOAc for three times (30 mL each time). The organic layers (CH2Cl2 and EtOAc) were combined and then evaporated. The separated solid was crystallized from mixture of DMF and ethanol (9:1) to obtain the corresponding compound as translucent solid. 4.5.29 (3-(4-Bromophenyl)-5-(2-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanone (D14) White crystal, mp: 199-201 ¡ãC. 1H NMR (CDCl3, 300 MHz) delta: 3.21-3.27 (m, 1H), 3.82-3.88 (m, 1H), 4.45-4.66 (m, 2H), 5.61-5.66 (m, 1H), 5.80-5.84 (m, 1H), 6.86-6.88 (m, 3H), 7.02-7.23 (m, 4H), 7.47 (m, 3H), 7.74-7.77 (d, J = 7.5 Hz, 2H). MS (ESI): 481.05 (C24H19BrFN2O3, [M+H]+). Anal. Calcd for C24H18BrFN2O3: C, 59.89; H, 3.77; Br, 16.60; F, 3.95; N, 5.82; O, 9.97. Found: C, 59.72; H, 3.75; N, 5.83., 3663-80-7

As the rapid development of chemical substances, we look forward to future research findings about 3663-80-7

Reference£º
Article; Yang, Yu-Shun; Li, Qing-Shan; Sun, Shuai; Zhang, Yan-Bin; Wang, Xiao-Liang; Zhang, Fei; Tang, Jian-Feng; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 20; 20; (2012); p. 6048 – 6058;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3663-80-7,2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid,as a common compound, the synthetic route is as follows.,3663-80-7

2-iodophenol as raw materials, synthesis of racemic doxazosin, the reaction line as follows:1. Synthesis of Compound c: The same procedure as in Example 1, c.2. Synthesis of compound f (i.e., doxazosin racemate)Compounds c were weighed into eggplant flasks,Plus tetrahydrofuran dissolved,The mixture was stirred for 5-10 minutes at room temperature until compound c was completely dissolved.N, N’-carbonyldiimidazole (1.1 equiv) was weighed and dissolved in tetrahydrofuran,Was slowly added dropwise to the above solution,The mixture was stirred at room temperature for 1 hour,The solution A was obtained.Another take a pickle-shaped bottle,The compound g (2-piperazinyl-4-amino-6,7-dimethoxyquinazoline) (1.0 equiv)Followed by stirring for 10 minutes with tetrahydrofuran. Solution A was slowly added dropwise to solution B at 0 ¡ã C, and the reaction was allowed to proceed to room temperature for 4 hours after completion of dropwise addition. The solid was filtered off. The solid was dissolved in acetone and refluxed for 6 hours. Upon cooling to room temperature, the solid was filtered off and washed with acetone and dried to give a white solid as Compound f (doxazosin racemate). Yield 80percent

3663-80-7 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid 2735450, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Patent; Guangzhou Institute Of Biomedicine And Health Chinese Academy Of Sciences; Cai, Qian; Huang, Yusha; (17 pag.)CN105985328; (2016); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid, cas is 3663-80-7, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

Method I Ba (1 mmol) and 2,3-dihydrobenzo[b][1,4]dioxin-6-carboxylic acid (or 2,3-dihydrobenzo[b][1,4]dioxin-2-carboxylic acid) (1 mmol) together with EDCI (1.5 mmol) and HOBt (0.05 mmol) in CH2Cl2 (20 mL) were refluxed at room temperature for 10 h. While the reaction completed, the solution was washed with water for three times (30 mL each time). The remaining water layer was extracted by EtOAc for three times (30 mL each time). The organic layers (CH2Cl2 and EtOAc) were combined and then evaporated. The separated solid was crystallized from mixture of DMF and ethanol (9:1) to obtain the corresponding compound as translucent solid. 4.5.30 (2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)(5-(2-fluorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)methanone (D15) White crystal, mp: 208-209 ¡ãC. 1H NMR (CDCl3, 300 MHz) delta: 3.17-3.24 (d, J = 17.4 Hz, 1H), 3.69-3.80 (m, 1H), 3.87 (s, 3H), 4.42-4.47 (d, J = 11.1 Hz, 1H), 4.52-4.56 (m, 1H), 5.64-5.67 (m, 1H), 5.77-5.83 (m, 1H), 6.86-6.91 (m, 3H), 6.95-6.98 (d, J = 9.0 Hz, 2H), 7.02-7.12 (m, 3H), 7.20-7.25 (m, 2H), 7.68-7.71 (d, J = 8.7 Hz, 2H). MS (ESI): 433.15 (C25H22FN2O4, [M+H]+). Anal. Calcd for C25H21FN2O4: C, 69.44; H, 4.89; F, 4.39; N, 6.48; O, 14.80. Found: C, 69.26; H, 4.87; N, 6.49., 3663-80-7

As the rapid development of chemical substances, we look forward to future research findings about 3663-80-7

Reference£º
Article; Yang, Yu-Shun; Li, Qing-Shan; Sun, Shuai; Zhang, Yan-Bin; Wang, Xiao-Liang; Zhang, Fei; Tang, Jian-Feng; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 20; 20; (2012); p. 6048 – 6058;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3663-80-7,2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid,as a common compound, the synthetic route is as follows.,3663-80-7

General procedure: The starting two acids (2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylic acid and 2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylic acid) shoud be activated by firstly SOCl2: acid (100 mg) and (6-10 mL) was mixed and stirred at reflux 80 ? for 4 hours. The reaction mixture was cooled and evaporated to give reactive acyl chloride obtained as an oil, which would be dissolved in ethyl acetate (5-6 mL) in the next step.

As the paragraph descriping shows that 3663-80-7 is playing an increasingly important role.

Reference£º
Article; Li, Dong-Dong; Fang, Fei; Li, Jing-Ran; Du, Qian-Ru; Sun, Jian; Gong, Hai-Bin; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry Letters; vol. 22; 18; (2012); p. 5870 – 5875;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

3663-80-7, 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,3663-80-7

Method I Ba (1 mmol) and 2,3-dihydrobenzo[b][1,4]dioxin-6-carboxylic acid (or 2,3-dihydrobenzo[b][1,4]dioxin-2-carboxylic acid) (1 mmol) together with EDCI (1.5 mmol) and HOBt (0.05 mmol) in CH2Cl2 (20 mL) were refluxed at room temperature for 10 h. While the reaction completed, the solution was washed with water for three times (30 mL each time). The remaining water layer was extracted by EtOAc for three times (30 mL each time). The organic layers (CH2Cl2 and EtOAc) were combined and then evaporated. The separated solid was crystallized from mixture of DMF and ethanol (9:1) to obtain the corresponding compound as translucent solid. 4.5.21 (3,5-Bis(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanone (D6) White crystal, mp: 171-172 ¡ãC. 1H NMR (CDCl3, 300 MHz) delta: 3.19-3.25 (d, J = 17.7 Hz, 1H), 3.69-3.78 (m, 1H), 3.81 (s, 6H), 4.33-4.39 (m, 1H), 4.56-4.60 (d, J = 10.1 Hz, 1H), 5.53-5.56 (m, 2H), 6.81-6.83 (d, J = 7.2 Hz, 2H), 6.89-6.93 (m, 4H), 7.14-7.16 (d, J = 8.7 Hz, 2H), 7.43-7.46 (d, J = 8.1 Hz, 2H), 7.78-7.80 (d, J = 7.8 Hz, 2H). MS (ESI): 445.17 (C26H25N2O5, [M+H]+). Anal. Calcd for C26H24N2O5: C, 70.26; H, 5.44; N, 6.30; O, 18.00. Found: C, 69.87; H, 5.44; N, 6.33.

3663-80-7 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid 2735450, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Article; Yang, Yu-Shun; Li, Qing-Shan; Sun, Shuai; Zhang, Yan-Bin; Wang, Xiao-Liang; Zhang, Fei; Tang, Jian-Feng; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 20; 20; (2012); p. 6048 – 6058;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem