Category: 3663-79-4

3663-79-4, One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. CAS : 3663-79-4, Name is Methyl 1,4-Benzodioxane-2-carboxylate, molecular formula is C10H10O4. In a Article，once mentioned of 3663-79-4

Synthesis and biological activity of novel carbacyclins having bicyclic substituents on the omega-chain

A number of carbacyclins having bicyclic substituents on the omega-chain have been synthesized and tested for antiplatelet aggregation activity in vitro (against collagen-induced aggregation of rat platelet), for reduction of systemic blood pressure in vivo (ability to reduce the blood pressure in anesthetized rat by iv injection), and for cytoprotective activity (protection against ethanol-induced rat gastric lesion). The most effective compound for each activity was [3aS-[2E,3aalpha,4alpha(3R),5beta,6aalpha]]-5-[hexahydro-5-hydroxy-4-[3-hydroxy-3-(2- indanyl)-1-propynyl]-2(1H)-pentalenylidene]pentanoic acid (compound 11a), while some 1,4-benzodioxan analogues had selectivity for organ-protective activity, and indan analogues showed selectivity in their antiaggregation activity.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. 3663-79-4, In my other articles, you can also check out more blogs about 3663-79-4

Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner.In a patent, 3663-79-4, name is Methyl 1,4-Benzodioxane-2-carboxylate, introducing its new discovery. Quality Control of Methyl 1,4-Benzodioxane-2-carboxylate

Synthesis and biological evaluation of a series of benzoxazole/ benzothiazole-containing 2,3-dihydrobenzo[b][1,4]dioxine derivatives as potential antidepressants

A series of benzoxazole/benzothiazole-2,3-dihydrobenzo[b][1,4]dioxine derivatives (5a-5d and 8a-8j) was synthesized. Compounds were evaluated for binding affinities at the 5-HT1A and 5-HT2A receptors. Antidepressant activities of the compounds were screened using the forced swimming test (FST) and the tail suspension test (TST). The results indicated that the compounds exhibited high affinities for the 5-HT1A and 5-HT2A receptors and showed a marked antidepressant-like activity. Compound 8g exhibited high affinities for the 5-HT1A (Ki = 17 nM) and 5-HT2A (Ki = 0.71 nM) receptors; it also produced a decrease of the immobility time and exhibited potent antidepressant-like effects in the FST and TST in mice.

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Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Safety of Methyl 1,4-Benzodioxane-2-carboxylate, However, they have proven to be challenging because of the mutual inactivation of both catalysts. 3663-79-4, name is Methyl 1,4-Benzodioxane-2-carboxylate. In an article，Which mentioned a new discovery about 3663-79-4

Synthesis and evaluation of novel 2,3-dihydrobenzo[b][1,4]dioxin- and indolealkylamine derivatives as potential antidepressants

A series of 2,3-dihydrobenzo[b][1,4]dioxin- and indolealkylamine derivatives were synthesized and the target compounds were evaluated for their binding affinities at the 5-HT1A receptor and serotonin transporter. Antidepressant-like activities of the compounds were screened using the tail suspension and forced swim tests in mice. Preliminary results indicated that the target compounds exhibited high binding affinities at the 5-HT1A receptor and serotonin transporter, and produced marked antidepressant-like effects. The best example from this study, compound 5, exhibited high binding affinities for the 5-HT1A receptor (Ki = 96 nM) and serotonin transporter (Ki = 9.8 nM). The intrinsic activity of compound 5 showed agonistic property to the 5-HT1A receptor and inhibition of the 5-HT transporter. Furthermore, compound 5 exhibited greater antidepressant efficacy than fluoxetine and showed acceptable pharmacokinetic properties. A series of 3-(2-(4-((2,3-dihydrobenzo[b][1,4]dioxin-3-yl)methyl) piperazin-1-yl)ethyl-1H-indole derivatives were synthesized and the target compounds were evaluated for their antidepressant activities in vitro and in vivo. The compounds described were also evaluated for dual 5-HTT and 5-HT 1A receptor activities.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Safety of Methyl 1,4-Benzodioxane-2-carboxylate, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 3663-79-4

Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner.In a patent, 3663-79-4, name is Methyl 1,4-Benzodioxane-2-carboxylate, introducing its new discovery. Computed Properties of C10H10O4

Cyclopentane derivatives

The disclosure relates to novel pentanor prostaglandin analogues, for example 15-(5-chloroindan-2-yl)-9alpha,11alpha,15-trihydroxy-16,17,18,19,20-pentanor-5-cis, 13-trans-prostadienoic acid and 15-(5-chloroindan-2-yl)-11alpha,15-dihydroxy-9-oxo-16,17,18,19,20-pentanor-5-cis,13-trans-prostadienoic acid and the 1-ester and 1-alcohol derivatives thereof, to a process for their manufacture, to compositions containing them, and to their use in a method of inducing luteolysis.

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Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Reactions catalyzed interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend on composition, collectively referred to as solvent effects. In a patent£¬Which mentioned a new discovery about COA of Formula: C10H10O4, COA of Formula: C10H10O4

Resolution of 2-substituted 1,4-benzodioxanes by entrainment

The methyl ester of 1,4-benzodioxane-2-carboxylic acid 1 and the mesylate of 2-hydroxymethyl-1,4-benzodioxane 2 are synthetic intermediates whose enantiomers can be advantageously used to prepare a number of enantiopure 2-substituted 1,4-benzodioxanes from readily accessible (¡À)-1,4-benzodioxane-2-carboxilic acid. We have previously demonstrated the conglomerate nature of the enantiomeric systems of 1 and 2. Herein, we report the resolution of their racemates by preferential crystallization according to an entrainment procedure. In particular, the entrainment resolution of 1 showed good efficiency, which makes the present method a competitive alternative to the classical resolutions of 1,4-benzodioxane-2-carboxylic acid with dehydroabietylamine and para-substituted 1-phenylethylamines that we have recently reported.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. COA of Formula: C10H10O4, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 3663-79-4, in my other articles.

Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Electric Literature of 3663-79-4, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 3663-79-4, Methyl 1,4-Benzodioxane-2-carboxylate, introducing its new discovery.

Regioselective acylation of benzodioxin derivatives employing AlCl3-DMSO or AlCl3-DMF reagent in the Friedel-Crafts reaction

A simple and efficient route to the regioselective acylation of benzodioxin derivatives using AlCl3-DMSO or AlCl3-DMF as reagent with acyl halides and anhydrides is described.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 3663-79-4. In my other articles, you can also check out more blogs about 3663-79-4

Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 3663-79-4, name is Methyl 1,4-Benzodioxane-2-carboxylate, introducing its new discovery. HPLC of Formula: C10H10O4

From 2-aminomethyl-1,4-benzodioxane enantiomers to unichiral 2-cyano- and 2-carbonyl-substituted benzodioxanes via dichloroamine

2-Substituted 1,4-benzodioxanes, such as 2-cyano-, 2-methoxycarbonyl-, 2-aminocarbonyl-, and 2-formyl-1,4-benzodioxane, are key synthons that for the most part are never described as enantiomers or are inadequately characterized for enantiomeric purity. They were prepared by quantitative N,N-dichlorination of (R)- and (S)-2-aminomethyl-1,4-benzodioxane and successive functional group conversions in high yields without any racemization of the stereogenic benzodioxane C(2).

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. SDS of cas: 3663-79-4. Introducing a new discovery about 3663-79-4, Name is Methyl 1,4-Benzodioxane-2-carboxylate

Crystallization-based resolution of 1,4-benzodioxane-2-carboxylic acid enantiomers via diastereomeric 1-phenylethylamides

Unlike the diastereomeric 1-phenylethylammonium salts, the diastereomeric N-1-phenylethylamides of (S)- and (R)-1,4-benzodioxane-2-carboxylic acid show significant differences in fusibility and solubility so as to be efficiently resolved by precipitation of the less soluble diastereomer (>98% de), while chromatographic purification of the unprecipitated fraction affords the more soluble one (>99% de). Overall, 95% of the former and 80% of the latter are recovered. The hydrolysis of the two resolved amides provides the two acid enantiomers and the resolving amine in quantitative yield and with unchanged stereoisomeric purity.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.SDS of cas: 3663-79-4, you can also check out more blogs about3663-79-4

Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

3663-79-4, Name is Methyl 1,4-Benzodioxane-2-carboxylate, belongs to benzodioxans compound, is a common compound. COA of Formula: C10H10O4In an article, once mentioned the new application about 3663-79-4.

Cyclopentane derivatives

The disclosure relates to novel pentanor prostaglandin analogues, for example 15-(5-chloroindan-2-yl)-9alpha,11alpha,15-trihydroxy-16,17,18,19,20-pentanor-5-cis, 13-trans-prostadienoic acid and 15-(5-chloroindan-2-yl)-11alpha,15-dihydroxy-9-oxo-16,17,18,19,20-pentanor-5-cis,13-trans-prostadienoic acid and the 1-ester and 1-alcohol derivatives thereof, to a process for their manufacture, to compositions containing them, and to their use in a method of inducing luteolysis.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 3663-79-4

Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, SDS of cas: 3663-79-4, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 3663-79-4, Name is Methyl 1,4-Benzodioxane-2-carboxylate, molecular formula is C10H10O4

Resolution of 2-substituted 1,4-benzodioxanes by entrainment

The methyl ester of 1,4-benzodioxane-2-carboxylic acid 1 and the mesylate of 2-hydroxymethyl-1,4-benzodioxane 2 are synthetic intermediates whose enantiomers can be advantageously used to prepare a number of enantiopure 2-substituted 1,4-benzodioxanes from readily accessible (¡À)-1,4-benzodioxane-2-carboxilic acid. We have previously demonstrated the conglomerate nature of the enantiomeric systems of 1 and 2. Herein, we report the resolution of their racemates by preferential crystallization according to an entrainment procedure. In particular, the entrainment resolution of 1 showed good efficiency, which makes the present method a competitive alternative to the classical resolutions of 1,4-benzodioxane-2-carboxylic acid with dehydroabietylamine and para-substituted 1-phenylethylamines that we have recently reported.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. SDS of cas: 3663-79-4, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 3663-79-4, in my other articles.

Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem