Category: 3663-79-4

New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 3663-79-4,Safety of Methyl 1,4-Benzodioxane-2-carboxylate, In a article, mentioned the application of 3663-79-4, molecular formula is C10H10O4

Rh-catalyzed asymmetric hydrogenation of various benzo[b][1,4]dioxine derivatives was successfully developed to prepare chiral 2-substituted 2,3-dihydrobenzo[1,4]dioxane derivatives using ZhaoPhos and N-methylation of ZhaoPhos ligands with high yields and excellent enantioselectivities (up to 99% yield, >99% enantiomeric excess (ee), turnover number (TON) = 24 000). Moreover, this asymmetric hydrogenation methodology, as the key step with up to 10 000 TON, was successfully applied to develop highly efficient synthetic routes for the construction of some important biologically active molecules, such as MKC-242, WB4101, BSF-190555, and (R)-doxazosin·HCl.

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Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Chemical Research Letters, May 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. Which mentioned a new discovery about SDS of cas: 3663-79-4, SDS of cas: 3663-79-4

A series of benzoxazole/benzothiazole-2,3-dihydrobenzo[b][1,4]dioxine derivatives (5a-5d and 8a-8j) was synthesized. Compounds were evaluated for binding affinities at the 5-HT1A and 5-HT2A receptors. Antidepressant activities of the compounds were screened using the forced swimming test (FST) and the tail suspension test (TST). The results indicated that the compounds exhibited high affinities for the 5-HT1A and 5-HT2A receptors and showed a marked antidepressant-like activity. Compound 8g exhibited high affinities for the 5-HT1A (Ki = 17 nM) and 5-HT2A (Ki = 0.71 nM) receptors; it also produced a decrease of the immobility time and exhibited potent antidepressant-like effects in the FST and TST in mice.

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Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 3663-79-4,SDS of cas: 3663-79-4, In a article, mentioned the application of 3663-79-4, molecular formula is C10H10O4

(R)-1,4-Benzodioxane-2-carboxilic acid (R)-1 was obtained by resolution of the racemic acid 1 with stoichiometric or nonstoichiometric (+)- dehydroabietylamine (+)-2 in high chemical yield and enantiomeric excess. (S)-1 was isolated from the mother liquors of the crystallisation of (R)-1·(+)-2 and its enantiomeric excess maximised by recrystallisation procedures involving a precipitation under kinetic control or, alternatively, by conversion into the methyl ester followed by a single crystallisation. The different mechanisms of the two S enrichments is well explained by the binary phase diagrams of the acid and of the ester, which show that the former is a racemic compound, whereas the latter a conglomerate. The DSC analyses were extended to 2-hydroxymethyl- and 2-mesyloxymethyl-1,4-benzodioxane, establishing that the alcohol forms a racemic compound, while its mesyl ester a conglomerate. On the basis of these results, different resolution strategies can be designed to obtain useful homochiral 2-substituted 1,4-benzodioxanes coupling the resolution of 1 via diastereomeric salt formation with the enantiomeric enrichments by recrystallisations, preferably of its conglomerate forming derivatives.

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Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Chemical Research Letters, May 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. Which mentioned a new discovery about Recommanded Product: 3663-79-4, Recommanded Product: 3663-79-4

2-Substituted 1,4-benzodioxanes, such as 2-cyano-, 2-methoxycarbonyl-, 2-aminocarbonyl-, and 2-formyl-1,4-benzodioxane, are key synthons that for the most part are never described as enantiomers or are inadequately characterized for enantiomeric purity. They were prepared by quantitative N,N-dichlorination of (R)- and (S)-2-aminomethyl-1,4-benzodioxane and successive functional group conversions in high yields without any racemization of the stereogenic benzodioxane C(2).

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Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Reference of 3663-79-4, Research speed reading in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic. In a document type is Article, and a compound is mentioned, 3663-79-4, Name is Methyl 1,4-Benzodioxane-2-carboxylate, introducing its new discovery.

A simple and efficient route to the regioselective acylation of benzodioxin derivatives using AlCl3-DMSO or AlCl3-DMF as reagent with acyl halides and anhydrides is described.

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Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Research speed reading in 2021.The prevalence of solvent effects has motivated developing quantitative kinetic, spectroscopic, and theoretical assessments of solvent structures and their interactions with reaction intermediates and transition states. HPLC of Formula: C10H10O4, In a article, mentioned the application of 3663-79-4, Name is Methyl 1,4-Benzodioxane-2-carboxylate, molecular formula is C10H10O4

The methyl ester of 1,4-benzodioxane-2-carboxylic acid 1 and the mesylate of 2-hydroxymethyl-1,4-benzodioxane 2 are synthetic intermediates whose enantiomers can be advantageously used to prepare a number of enantiopure 2-substituted 1,4-benzodioxanes from readily accessible (±)-1,4-benzodioxane-2-carboxilic acid. We have previously demonstrated the conglomerate nature of the enantiomeric systems of 1 and 2. Herein, we report the resolution of their racemates by preferential crystallization according to an entrainment procedure. In particular, the entrainment resolution of 1 showed good efficiency, which makes the present method a competitive alternative to the classical resolutions of 1,4-benzodioxane-2-carboxylic acid with dehydroabietylamine and para-substituted 1-phenylethylamines that we have recently reported.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. HPLC of Formula: C10H10O4, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 3663-79-4, in my other articles.

Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Research speed reading in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic. Recommanded Product: 3663-79-4, In a article, mentioned the application of 3663-79-4, Name is Methyl 1,4-Benzodioxane-2-carboxylate, molecular formula is C10H10O4

A series of 2,3-dihydrobenzo[b][1,4]dioxin- and indolealkylamine derivatives were synthesized and the target compounds were evaluated for their binding affinities at the 5-HT1A receptor and serotonin transporter. Antidepressant-like activities of the compounds were screened using the tail suspension and forced swim tests in mice. Preliminary results indicated that the target compounds exhibited high binding affinities at the 5-HT1A receptor and serotonin transporter, and produced marked antidepressant-like effects. The best example from this study, compound 5, exhibited high binding affinities for the 5-HT1A receptor (Ki = 96 nM) and serotonin transporter (Ki = 9.8 nM). The intrinsic activity of compound 5 showed agonistic property to the 5-HT1A receptor and inhibition of the 5-HT transporter. Furthermore, compound 5 exhibited greater antidepressant efficacy than fluoxetine and showed acceptable pharmacokinetic properties. A series of 3-(2-(4-((2,3-dihydrobenzo[b][1,4]dioxin-3-yl)methyl) piperazin-1-yl)ethyl-1H-indole derivatives were synthesized and the target compounds were evaluated for their antidepressant activities in vitro and in vivo. The compounds described were also evaluated for dual 5-HTT and 5-HT 1A receptor activities.

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Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Research speed reading in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic. Product Details of 3663-79-4, In a article, mentioned the application of 3663-79-4, Name is Methyl 1,4-Benzodioxane-2-carboxylate, molecular formula is C10H10O4

A general method for the regioselective solvent free Friedel-Crafts acylation of 2-substituted-1,4-benzodioxin derivatives in excellent yields employing the AlCl3-DMA reagent with acyl halides or anhydrides as acylating agents is described. The acylation of 2-substituted-1,4-benzodioxin derivatives provides the 6-acyl compound as the major product. However, the saturated analogs affords the 7-acyl regioisomer as the main compound.

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Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Reference of 3663-79-4, New Advances in Chemical Research, May 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In a document type is Article, and a compound is mentioned, 3663-79-4, Name is Methyl 1,4-Benzodioxane-2-carboxylate, introducing its new discovery.

The synthesis of both enantiomers of 1,4-benzodioxan-2-carboxylic acid 1, a key synthetic intermediate for the therapeutic agents piperoxan, prosympal, dibozane, and doxazosin was achieved with good yields and high enantioselectivities via the Arthrobacter sp. lipase catalyzed kinetic resolution of ester (±)-17a. The influence of the co-solvents and the immobilization of the lipase upon kinetic resolution demonstrated that immobilized whole cells, in the presence of n-butanol as a co-solvent, resulted in the optimal resolution of the substrate (ee ?99%, E = 535) at 258 mmol (50 g/L) substrate concentration.

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Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Electric Literature of 3663-79-4,New Advances in Chemical Research in 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. 3663-79-4, Name is Methyl 1,4-Benzodioxane-2-carboxylate,introducing its new discovery.

Hexokinase 2 (HK2) is over-expressed in most of human cancers and has been proved to be a promising target for cancer therapy. In this study, based on the structure of HK2, we screened over 6 millions of compounds to obtain the lead. A total of 26 (E)-N?-(2,3,4-trihydroxybenzylidene) arylhydrazide derivatives were then designed, synthesized, and evaluated for their HK2 enzyme activity and IC50 values against two cancer cell lines. Most of the 26 target compounds showed excellently in vitro activity. Among them, compound 3j showed the strongest inhibitory effects on HK2 enzyme activity with an IC50 of 0.53 ± 0.13 muM and exhibited the most potent growth inhibition against SW480 cells with an IC50 of 7.13 ± 1.12 muM, which deserves further studies.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 3663-79-4. You can get involved in discussing the latest developments in this exciting area about 3663-79-4

Reference：
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem