Category: 274910-19-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.274910-19-9,(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol,as a common compound, the synthetic route is as follows.

A solution of 20 (3.75 g, 32.3 mmol) in diethyl ether (80 mL) was cooled to 0 C and phosphorous tribromide (3.67 mL, 38.8 mmol) was added dropwise. The solution was stirred at 0 C for 10 min, then at r.t. for 1 h. Water (10 mL) was added cautiously to quench the excess of reagent and the mixture was diluted with diethyl ether and washed with water (3 x 50 mL). The combined organic layers were washed with brine (100 mL), dried over Na2S04, filtered and concentrated under reduced pressure to obtain 21 as a brown solid (4.61 g, 62%). 1H NMR (CDCI3) delta 6.91-6.77 (m, 3H), 4.52 (s, 2H), 4.35-4.33 (m, 2H), 4.29-4.27 (m, 2H). Found: [M+H- Br]=149.5., 274910-19-9

274910-19-9 (2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol 2776182, abenzodioxans compound, is more and more widely used in various.

Reference£º
Patent; THE GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT, INC.; UPTON, Anna, Marie; COOPER, Christopher, Blair; MARCEL, Koenraad, Jozel Lodewijk; GUILLEMONT, Jerome, Emile Goerges; VAN DEN BROECK, Walter Marcel, Mathilde; PALMER, Brian, Desmond; MA, Zhenkun; (186 pag.)WO2017/155909; (2017); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

274910-19-9, (2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,274910-19-9

N5-Cyclobutyl-N3-methyl-2-oxo-1, 2-d ihydropyrid ine-3,5-d icarboxamide (50 mg, 0.201mmol), (2,3-dihydrobenzo[b][1,4]dioxin-5-yl)methanol (50.0 mg, 0.301 mmol) and 2-(tributylphosphoranylidene)acetonitrile (0.166 mL, 0.632 mmol) were combined in toluene (1.5 mL)and the reaction mixture heated in a 5 mL microwave vial on a Biotage Initiator microwave at 120C for 30 mm. The reaction mixture was poured onto water (20 mL), and extracted with ethylacetate (3 x 10 mL). The combined organic portions were evaporated in vacuo to yield the crude product as a brown oil. The product was loaded in dichloromethane onto a 25 g SNAP silica cartridge and purified via Biotage 5P4 flash chromatography, eluting from 50 – 100 % ethyl acetate/cyclohexane. The relevant fractions were combined and evaporated in vacuo – yielding 76mg of product. The sample was dissolved in MeOH/DMSO (1 mL, 1:1) and purified by MDAP (Formic). The solvent was evaporated in vacuoto give the required product – N5-cyclobutyl-1-((2,3- dihyd robenzo[b] [1,4]d ioxin-5-yl)methyl)-N3-methyl-2-oxo-1, 2-d ihydropyrid ine-3,5-dicarboxamide(40 mg, 0.096 mmol, 47.7 % yield).LCMS (2 mm Formic): Rt = 0.95 mi [MH] = 398.1.

274910-19-9 (2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol 2776182, abenzodioxans compound, is more and more widely used in various.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen John; AYLOTT, Helen Elizabeth; COOPER, Anthony William James; DEMONT, Emmanuel Hubert; HARRISON, Lee Andrew; HAYHOW, Thomas George Christopher; LINDON, Matthew J; PRESTON, Alexander G; SEAL, Jonathan Thomas; WALL, Ian David; WATSON, Robert J; WOOLVEN, James Michael; (308 pag.)WO2017/37116; (2017); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

274910-19-9, (2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(3) 2,3-ethylenedioxybenzyl chloride 4.3 g of 2,3-ethylenedioxybenzyl alcohol was dissolved in 50 ml of dry dichloromethane. Then, 2.1 ml of dry pyridine was dropwise added thereto, and 3.8 ml of thionyl chloride was gradually added under cooling. The reaction solution was returned to room temperature and then the reaction solution was refluxed for 3 hours on a hot water bath at 60 C. The reaction solution was concentrated under reduced pressure to obtain a syrup, which was then dissolved in 300 ml of ethyl acetate. The solution was washed with 200 ml of 0.1N hydrochloric acid and then twice with 200 ml of a saturated sodium chloride aqueous solution. Then, the solution was dried over anhydrous magnesium sulfate. The inorganic salt was removed by filtration, and the filtrate was concentrated under reduced pressure and purified by silica gel column chromatography (n-hexane/ethyl acetate=60/1) to obtain 4.0 g of the above identified compound as syrup. Rf: 0.64 (n-hexane/ethyl acetate=2/1)., 274910-19-9

274910-19-9 (2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol 2776182, abenzodioxans compound, is more and more widely used in various.

Reference£º
Patent; Banyu Pharmaceutical Co., Ltd.; US5122523; (1992); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol, cas is 274910-19-9, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol (533 mg, 3.20 mmol) is dissolved in chloroform (4 mL), pyridine (0.11 mL) and thionyl chloride (0.7 mL, 9.7 mmol) is added little by little and the mixture is stirred at room temperature for 1 hour. The reaction solution is added with water and extracted with dichloromethane, and the organic layer is washed with aqueous sodium hydrogen carbonate solution. The organic layer is dried, the solvent is distilled off under reduced pressure, and pale yellow liquid of 578 mg is obtained in 97% yield.

With the rapid development of chemical substances, we look forward to future research findings about 274910-19-9

Reference£º
Patent; KANTO KAGAKU KABUSHIKI KAISHA; ABE, Jiro; INAGAKI, Yuki; SUGA, Takayoshi; NAGASAWA, Hiroto; US2020/131193; (2020); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

274910-19-9, (2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,3-Dihydro-1,4-benzodioxin-5-ylinethanol (1.01 g, 6.07 mmol) was dissolved in methylene chloride (60 mL). Manganese dioxide (3.81 g, 43.8 mmol) was added, and then the mixture was stirred in a nitrogen atmosphere at room temperature for 24 hours. Manganese dioxide was separated by filtration and the solvent was evaporated under reduced pressure. The resulting residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane = 1/4) to give the target compound (835 mg, yield: 84%) as a colorless oil. 1H-NMR (CDCl3, 400MHz):delta ppm: 4.32-4.34 (2H, m), 4.38-4.41 (2H, m), 6.91 (1H, t, J=7.8Hz), 7.10 (1H, dd, J=1.6, 7.8Hz), 7.40 (1H, dd, J=1.6, 7.8Hz). MS (EI) m/z: 164.0468 (M+)

The synthetic route of 274910-19-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Daiichi Sankyo Company, Limited; EP1914229; (2008); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.274910-19-9,(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol,as a common compound, the synthetic route is as follows.

[00209j A mixture of Intermediate 1(500mg, 1.5 mmol), (2,3-dihydrobenzo[b][1,4] dioxin-5-yl)methanol (380 mg, 2.3 mmol) and Cs2CO3 (1000 mg, 3.1 mmol) in DMSO (5 mL) was stirred for 2 days at 120 C. The reaction mixture was diluted with water andbrine (1:1, 50 mL) and extracted with EtOAc (2 x 30 mL). The combined organics were washed with brine, dried over Na2504 and concentrated in vacuo. The crude product was purified by column chromatography to yield the Example 2A (400 mg, 0.97 mmol, 63% yield), as a brown oil. MS (ESI) m/z 412.2 (M+H).

The synthetic route of 274910-19-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WURTZ, Nicholas R.; VIET, Andrew Quoc; SHAW, Scott A.; VOKITS, Benjamin P.; KICK, Ellen K.; VALENTE, Meriah Neissel; DILGER, Andrew K.; PABBISETTY, Kumar Balashanmuga; JUSUF, Sutjano; (140 pag.)WO2016/40417; (2016); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.274910-19-9,(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol,as a common compound, the synthetic route is as follows.

2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol (533 mg, 3.20 mmol) is dissolved in chloroform (4 mL), pyridine (0.11 mL) and thionyl chloride (0.7 mL, 9.7 mmol) is added little by little and the mixture is stirred at room temperature for 1 hour. The reaction solution is added with water and extracted with dichloromethane, and the organic layer is washed with aqueous sodium hydrogen carbonate solution. The organic layer is dried, the solvent is distilled off under reduced pressure, and pale yellow liquid of 578 mg is obtained in 97% yield.

The synthetic route of 274910-19-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KANTO KAGAKU KABUSHIKI KAISHA; ABE, Jiro; INAGAKI, Yuki; SUGA, Takayoshi; NAGASAWA, Hiroto; US2020/131193; (2020); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem