Category: 20197-75-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20197-75-5,Methyl 1,4-Benzodioxan-6-carboxylate,as a common compound, the synthetic route is as follows.

(2) Synthesis of Compound 1 (0146) The compound k (2.01 g), NBS (8.48 g), and carbon tetrachloride (125 ml) were introduced to an eggplant-shaped flask. Then, AIBN (340 mg) was added thereto in a nitrogen atmosphere and heated to reflux for 44 hours. The reaction solution was extracted with chloroform. Subsequently, the extract was washed with saturated saline, dehydrated with sodium sulfate, and concentrated. The concentrate was purified by silica gel column chromatography (Wakosil? C-300) using chloroform alone as an eluent. Thus, the compound 1 was obtained (yield: 2.64 g; yield rate: 73percent).

20197-75-5, As the paragraph descriping shows that 20197-75-5 is playing an increasingly important role.

Reference£º
Patent; RIKEN; Nakano, Takeshi; ASAMI, Tadao; OSADA, Hiroyuki; (31 pag.)US2017/305886; (2017); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

20197-75-5, Methyl 1,4-Benzodioxan-6-carboxylate is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,20197-75-5

(3) step (2) the obtained solid product, ethanol, reflux reaction of hydrazine hydrate, the obtained solid product;Step (2) the obtained solid product, ethanol, the proportion of the amount of the hydrazine hydrate is 0.1: 2 : 0.5, wherein step (2) in the obtained solid product of mmol, ethanol, hydrazine hydrate to meter ml, reflux the reaction time is 15h.

The synthetic route of 20197-75-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shandong University of Technology; Shu, Juan; Lian, Zhimin; Zhu, Hailiang; Xu, Yizeng; Sun, Liqin; gao, Leilei; (12 pag.)CN105777731; (2016); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20197-75-5,Methyl 1,4-Benzodioxan-6-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 60% NaH (0.12g, 5mmol) was added in anhydrous THF (10mL), followed by the addition of anhydrous CH3CN (0.21g, 5mmol) and compound 2 (0.42g, 2.5mmol) in the ice bath. Reaction was heated to reflux and stirred for 6h. Upon completion, the reaction mixture was taken up in ice water (30mL) and the pH was adjusted to 5. After filtration, the filtrate was extracted with ethyl acetate (20mL¡Á3). The combined organic phase was washed twice with saturated brine (20mL¡Á2) and dried over anhydrous MgSO4. Then, MgSO4 was filtered out, and the filtrate was concentrated in vacuo, Followed by recrystallization of the residue to afford compound 19a as a pale-yellow solid., 20197-75-5

20197-75-5 Methyl 1,4-Benzodioxan-6-carboxylate 3802178, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Article; Heng, Hao; Wang, Zhijie; Li, Hongmei; Huang, Yatian; Lan, Qingyuan; Guo, Xiaoxing; Zhang, Liang; Zhi, Yanle; Cai, Jiongheng; Qin, Tianren; Xiang, Li; Wang, Shuxian; Chen, Yadong; Lu, Tao; Lu, Shuai; European Journal of Medicinal Chemistry; vol. 176; (2019); p. 248 – 267;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

20197-75-5, Methyl 1,4-Benzodioxan-6-carboxylate is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

will be 1, 4 – benzene and dioxane -6 – methyl formate (26.0g, 133 . 9mmol) by adding acetic acid (150 ml) in, stirring to dissolve, dropping fuming nitric acid (51 ml), canada finishes, heating up to 70 ¡ãC stirring 1 hour. Cooling to room temperature, concentrated under reduced pressure, for 5percent of sodium hydroxide aqueous solution to adjust the pH to 7, adding ethyl acetate, the organic phase after the water washing, drying, concentration, be 7 – nitro – 2, 3 – dihydrobenzo [b] [1, 4] dioxin -6 – carboxylic acid methyl ester (31.1g, 97percent).

20197-75-5, 20197-75-5 Methyl 1,4-Benzodioxan-6-carboxylate 3802178, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Patent; Shanghai Huilun Life Technology Co., Ltd.; Cheng Jianjun; Qin Jihong; (25 pag.)CN104557955; (2017); B;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

A common heterocyclic compound, the benzodioxans compound, name is Methyl 1,4-Benzodioxan-6-carboxylate,cas is 20197-75-5, mainly used in chemical industry, its synthesis route is as follows.

To a solution of compound A(0.1 mol) in ethanol (50 mL) was added 85% hydrazine hydrate (1 mL) and the mixture was refluxed for 8-10 h. The reaction mixture was cooled down and the precipitated solid was filtered off and washed with small quantity of ethanol to give intermediate compound B.

20197-75-5, As the rapid development of chemical substances, we look forward to future research findings about 20197-75-5

Reference£º
Article; Wang; Liu; Xu; Sun; Russian Journal of General Chemistry; vol. 87; 11; (2017); p. 2671 – 2677; Zh. Obshch. Khim.; vol. 87; 11; (2017); p. 2671 – 2677,7;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

20197-75-5, Methyl 1,4-Benzodioxan-6-carboxylate is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 121 7-Nitro-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester Nitric Acid (18 mL) was added dropwise to a solution of 15.0 g (77.3 mmol) of 2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester in 45 mL of HOAc. The solution was heated at 60¡ã C. for 1.5 h. An additional 9 mL of HNO3 was then added and heating was continued for 1.5 h at 70¡ã C. The reaction was poured into ice-H2O and the solid product was collected, washed well with H2O and dried. Recrystallization from heptane-toluene yielded 16.8 g of the title compound as yellow crystals: mass spectrum (electron impact, m/e): 239., 20197-75-5

As the paragraph descriping shows that 20197-75-5 is playing an increasingly important role.

Reference£º
Patent; American Cyanamid Company; US6288082; (2001); B1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

20197-75-5, Methyl 1,4-Benzodioxan-6-carboxylate is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A stirred solution of compound 3 (0.1 mol) in ethanol (50 mL) was treated with the hydrazine hydrate (85%), under 90 oC for 5 d. The sovlent was removed leaving oil which was dissovled in ethyl acetate (20 ml) and extracted with water (40 ml). After drying the organic layer with anhydrous Na2SO4 and evaporating the solvent under reduced pressure a solid appeared. The solid was recyrstallized from ethanol to obtain the compound 6.

20197-75-5, 20197-75-5 Methyl 1,4-Benzodioxan-6-carboxylate 3802178, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Article; Sun, Juan; Li, Ming-Hui; Qian, Shao-Song; Guo, Feng-Jiao; Dang, Xiao-Fang; Wang, Xiao-Ming; Xue, Ya-Rong; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry Letters; vol. 23; 10; (2013); p. 2876 – 2879;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20197-75-5,Methyl 1,4-Benzodioxan-6-carboxylate,as a common compound, the synthetic route is as follows.,20197-75-5

Step B: Preparation of 6-nitro-3,4-ethylenedioxybenzoic acid methyl ester. To a solution of 5.0 g. of 3,4-ethylenedioxybenzoic acid methyl ester in 5.0 mls. of glacial acetic acid is added dropwise 5.0 mls. of 70percent nitric acid at 50¡ã-60¡ã C. After addition the reaction mixture is kept at 55¡ã C. for one hour, then cooled and 50 mls. of ice water added. The resulting precipitate is recovered by filtering, water washed and dried to obtain 6-nitro-3,4-ethylenedioxybenzoic acid methyl ester, m.p. 115¡ã-118¡ã C.

20197-75-5 Methyl 1,4-Benzodioxan-6-carboxylate 3802178, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Patent; Sandoz, Inc.; US4011323; (1977); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20197-75-5,Methyl 1,4-Benzodioxan-6-carboxylate,as a common compound, the synthetic route is as follows.,20197-75-5

To a solution of compound 2 (1 mmol) in ethanol (15 mL) wasadded hydrazine hydrate (10 mmol), and the mixture was heatedat reflux for 2 days. Excessive ethanol was distilled out and thecontents were allowed to cool. The crystals formed, collected by filtrationand washed several times with ethanol to obtain compound3. The completion of the reaction was monitored on TLC by usingmethanol and ethyl acetate (1:10) and observed in UV light.

20197-75-5 Methyl 1,4-Benzodioxan-6-carboxylate 3802178, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Article; Sun, Juan; Ren, Shen-Zhen; Lu, Xiao-Yuan; Li, Jing-Jing; Shen, Fa-Qian; Xu, Chen; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 25; 9; (2017); p. 2593 – 2600;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20197-75-5,Methyl 1,4-Benzodioxan-6-carboxylate,as a common compound, the synthetic route is as follows.,20197-75-5

Protocatechuic acid (0.0973 mol, 15 g) was dissolved in methanol (100 ml) with stirring,catalyzed by concentrated sulfuric acid. The mixture was stirred for about 20 h at 63C and evaporated. The concentratedsolution was poured into 200 ml of ethyl acetate and 100 ml of water and stilled. The ethyl acetate solvent was evaporated togive white powdered compound 1.Compound 1 (0.06 mol, 10.0824 g) and 1,2-dibromoethane (0.12 mol, 10.45 ml) were dissolved in acetone (100 ml)with stirring, using K2CO3 (0.24 mol, 33.16 g) as the acid binding agent. The mixture was stirred for about 24 h at 56C. Theinsoluble substance was removed by filtration; the solvent was evaporated to obtain yellow powdered compound 2.A mixture of compound 2 (0.01 mol, 1.9406 g) and hydrazine hydrate (0.064 mol, 3.1 ml) in ethanol (200 ml) wasstirred at 80C for 24 h. The solvent was evaporated to gain white powdered compound 3.

The synthetic route of 20197-75-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Sheng; Wang; Feng; Gao; Zhu; Journal of Structural Chemistry; vol. 59; 1; (2018); p. 140 – 144; Zh. Strukt. Kim.; vol. 59; 1; (2018); p. 144 – 148,5;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem