Category: 20197-75-5

20197-75-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Methyl 1,4-Benzodioxan-6-carboxylate, cas is 20197-75-5,the benzodioxans compound, it is a common compound, a new synthetic route is introduced below.

will be 1, 4 – benzene and dioxane -6 – methyl formate (26.0g, 133 . 9mmol) by adding acetic acid (150 ml) in, stirring to dissolve, dropping fuming nitric acid (51 ml), canada finishes, heating up to 70 ¡ãC stirring 1 hour. Cooling to room temperature, concentrated under reduced pressure, for 5percent of sodium hydroxide aqueous solution to adjust the pH to 7, adding ethyl acetate, the organic phase after the water washing, drying, concentration, be 7 – nitro – 2, 3 – dihydrobenzo [b] [1, 4] dioxin -6 – carboxylic acid methyl ester (31.1g, 97percent).

The chemical industry reduces the impact on the environment during synthesis,20197-75-5,Methyl 1,4-Benzodioxan-6-carboxylate,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; Shanghai Huilun Life Technology Co., Ltd.; Cheng Jianjun; Qin Jihong; (25 pag.)CN104557955; (2017); B;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

As a common heterocyclic compound, it belongs to benzodioxans compound, name is Methyl 1,4-Benzodioxan-6-carboxylate, and cas is 20197-75-5, its synthesis route is as follows.

To a solution of compound A(0.1 mol) in ethanol (50 mL) was added 85% hydrazine hydrate (1 mL) and the mixture was refluxed for 8-10 h. The reaction mixture was cooled down and the precipitated solid was filtered off and washed with small quantity of ethanol to give intermediate compound B.

20197-75-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,20197-75-5 ,Methyl 1,4-Benzodioxan-6-carboxylate, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Wang; Liu; Xu; Sun; Russian Journal of General Chemistry; vol. 87; 11; (2017); p. 2671 – 2677; Zh. Obshch. Khim.; vol. 87; 11; (2017); p. 2671 – 2677,7;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

As a common heterocyclic compound, it belongs to benzodioxans compound, name is Methyl 1,4-Benzodioxan-6-carboxylate, and cas is 20197-75-5, its synthesis route is as follows.

In the atmosphere of nitrogen,Dimethyl dimethyl phosphate (514 mg, 4.15 mmol, 1.5 eq) was dissolved in 5 ml of dry tetrahydrofuran,Cool to -60¡ãC with dry ice/ethanol.Slowly add n-butyllithium (2.2 mL, 2.5 mol/mL)N-hexane solution, 5.54 mmol, 2 eq),The mixture is stirred at this temperature for 30 minutes.A solution of the compound benzodioxane-6-carboxylic acid methyl ester (0402-119) (538 mg, 2.77 mmol, 1 eq) in tetrahydrofuran (1 ml) was slowly added dropwise.The mixture was stirred at -60¡ãC for 1 hour.After the reaction is completed, quenched with saturated aqueous ammonium chloride, using BEthyl acetate was extracted and the organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the target product (2-(Benzo)Dioxane-6-yl)-2-oxoethyl) dimethyl phosphate (754 mg, crude) was a yellow oil.

20197-75-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,20197-75-5 ,Methyl 1,4-Benzodioxan-6-carboxylate, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

Name is Methyl 1,4-Benzodioxan-6-carboxylate, as a common heterocyclic compound, it belongs to benzodioxans compound, and cas is 20197-75-5, its synthesis route is as follows.,20197-75-5

will be 1, 4 – benzene and dioxane -6 – methyl formate (26.0g, 133 . 9mmol) by adding acetic acid (150 ml) in, stirring to dissolve, dropping fuming nitric acid (51 ml), canada finishes, heating up to 70 ¡ãC stirring 1 hour. Cooling to room temperature, concentrated under reduced pressure, for 5percent of sodium hydroxide aqueous solution to adjust the pH to 7, adding ethyl acetate, the organic phase after the water washing, drying, concentration, be 7 – nitro – 2, 3 – dihydrobenzo [b] [1, 4] dioxin -6 – carboxylic acid methyl ester (31.1g, 97percent).

With the complex challenges of chemical substances, we look forward to future research findings about Methyl 1,4-Benzodioxan-6-carboxylate

Reference£º
Patent; Shanghai Huilun Life Technology Co., Ltd.; Cheng Jianjun; Qin Jihong; (25 pag.)CN104557955; (2017); B;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

As a common heterocyclic compound, it belongs to benzodioxans compound, name is Methyl 1,4-Benzodioxan-6-carboxylate, and cas is 20197-75-5, its synthesis route is as follows.,20197-75-5

Step B Preparation of 6-nitro-3,4-ethylenedioxybenzoic acid methyl ester To a solution of 5.0 g. of 3,4-ethylenedioxybenzoic acid methyl ester in 5.0 mls. of glacial acetic acid is added dropwise 5.0 mls. of 70percent nitric acid at 50¡ã-60¡ãC. After addition the reaction mixture is kept at 55¡ãC. for one hour, then cooled and 50 mls. of ice water added. The resulting precipitate is recovered by filtering, water washed and dried to obtain 6-nitro-3,4-ethylenedioxybenzoic acid methyl ester, m.p. 115¡ã-118¡ãC.

With the complex challenges of chemical substances, we look forward to future research findings about 20197-75-5,belong benzodioxans compound

Reference£º
Patent; Sandoz Inc.; US3931179; (1976); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

Name is Methyl 1,4-Benzodioxan-6-carboxylate, as a common heterocyclic compound, it belongs to benzodioxans compound, and cas is 20197-75-5, its synthesis route is as follows.,20197-75-5

To a solution of compound 2 (1 mmol) in ethanol (15 mL) wasadded hydrazine hydrate (10 mmol), and the mixture was heatedat reflux for 2 days. Excessive ethanol was distilled out and thecontents were allowed to cool. The crystals formed, collected by filtrationand washed several times with ethanol to obtain compound3. The completion of the reaction was monitored on TLC by usingmethanol and ethyl acetate (1:10) and observed in UV light.

With the complex challenges of chemical substances, we look forward to future research findings about Methyl 1,4-Benzodioxan-6-carboxylate

Reference£º
Article; Sun, Juan; Ren, Shen-Zhen; Lu, Xiao-Yuan; Li, Jing-Jing; Shen, Fa-Qian; Xu, Chen; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 25; 9; (2017); p. 2593 – 2600;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO156,mainly used in chemical industry, its synthesis route is as follows.,20197-75-5

(2) Synthesis of Compound 1 (0146) The compound k (2.01 g), NBS (8.48 g), and carbon tetrachloride (125 ml) were introduced to an eggplant-shaped flask. Then, AIBN (340 mg) was added thereto in a nitrogen atmosphere and heated to reflux for 44 hours. The reaction solution was extracted with chloroform. Subsequently, the extract was washed with saturated saline, dehydrated with sodium sulfate, and concentrated. The concentrate was purified by silica gel column chromatography (Wakosil? C-300) using chloroform alone as an eluent. Thus, the compound 1 was obtained (yield: 2.64 g; yield rate: 73percent).

With the complex challenges of chemical substances, we look forward to future research findings about Methyl 1,4-Benzodioxan-6-carboxylate,belong benzodioxans compound

Reference£º
Patent; RIKEN; Nakano, Takeshi; ASAMI, Tadao; OSADA, Hiroyuki; (31 pag.)US2017/305886; (2017); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

Name is Methyl 1,4-Benzodioxan-6-carboxylate, as a common heterocyclic compound, it belongs to benzodioxans compound, and cas is 20197-75-5, its synthesis route is as follows.,20197-75-5

To a solution of 2a (1.16 g, 6.0 mmol) in EtOH (30 mL) was added hydrazine hydrate (2.91 mL, 60 mmol) and the mixture was heated at reflux for 2 days. After cooling to room temperature pure crystals are formed, collected by filtration and washed several times with EtOH to give compound 3a (0.87 g, 75%) as a light yellow solid. 1H NMR (DMSO-d6, 500 MHz): delta [ppm] = 4.28 (2H, m), 4.30 (2H, m), 6.89 (1H, d, J = 8.4 Hz), 7.30 (1H, dd, J = 8.3 Hz, J = 2.1 Hz), 7.33 (1H, d, J = 2.1 Hz). 13C NMR (DMSO-d6, 125 MHz): delta [ppm] = 65.9, 66.3, 117.9, 118.6, 121.9, 127.5, 145.2, 148.6, 169.6. EI-MS: m/z 194 (M+).

With the complex challenges of chemical substances, we look forward to future research findings about Methyl 1,4-Benzodioxan-6-carboxylate

Reference£º
Article; Lo Monte, Fabio; Kramer, Thomas; Gu, Jiamin; Brodrecht, Martin; Pilakowski, Johannes; Fuertes, Ana; Dominguez, Juan Manuel; Plotkin, Batya; Eldar-Finkelman, Hagit; Schmidt, Boris; European Journal of Medicinal Chemistry; vol. 61; (2013); p. 26 – 40;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

As a common heterocyclic compound, it belongs to benzodioxans compound, name is Methyl 1,4-Benzodioxan-6-carboxylate, and cas is 20197-75-5, its synthesis route is as follows.,20197-75-5

In the atmosphere of nitrogen,Dimethyl dimethyl phosphate (514 mg, 4.15 mmol, 1.5 eq) was dissolved in 5 ml of dry tetrahydrofuran,Cool to -60¡ãC with dry ice/ethanol.Slowly add n-butyllithium (2.2 mL, 2.5 mol/mL)N-hexane solution, 5.54 mmol, 2 eq),The mixture is stirred at this temperature for 30 minutes.A solution of the compound benzodioxane-6-carboxylic acid methyl ester (0402-119) (538 mg, 2.77 mmol, 1 eq) in tetrahydrofuran (1 ml) was slowly added dropwise.The mixture was stirred at -60¡ãC for 1 hour.After the reaction is completed, quenched with saturated aqueous ammonium chloride, using BEthyl acetate was extracted and the organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the target product (2-(Benzo)Dioxane-6-yl)-2-oxoethyl) dimethyl phosphate (754 mg, crude) was a yellow oil.

With the complex challenges of chemical substances, we look forward to future research findings about 20197-75-5,belong benzodioxans compound

Reference£º
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

Methyl 1,4-Benzodioxan-6-carboxylate, cas is 20197-75-5, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.,20197-75-5

Nitric Acid (18 mL) was added dropwise to a solution of 15.0 g (77.3 mmol) of 2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester in 45 mL of HOAc. The solution was heated at 60C for 1.5 h. An additional 9 mL of HNO3 was then added and heating was continued for 1.5 h at 70C. The reaction was poured into ice-H2O and the solid product was collected, washed well with H2O and dried. Recrystallization from heptane-toluene yielded 16.8 g of the title compound as yellow crystals: mass spectrum (electron impact, m/e): 239.

20197-75-5 is used more and more widely, we look forward to future research findings about Methyl 1,4-Benzodioxan-6-carboxylate

Reference£º
Patent; Wyeth Holdings Corporation; EP1117659; (2003); B1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem