Category: 1975-50-4

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 1975-50-4, Name is 2-Methyl-3-nitrobenzoic acid, molecular formula is C8H7NO4. In an article, author is Mironov, Vladimir F.,once mentioned of 1975-50-4, Recommanded Product: 2-Methyl-3-nitrobenzoic acid.

Catalytic (ZnCl2, Et3N) phosphorylation of tert-butylacetyl-acetone with 2-chloro-1,3,2-benzodioxaphosphole unexpectedly occurs with elimination of proton from the methyl group and leads to vinyloxyphosphole derivative, viz., 4-(1,3,2-benzodioxa-phosphol-2-yloxy)-3-tert-butylpent-4-en-2-one. Its reaction with hexafluoroacetone gives a cage phosphorane as a result of subsequent chemoselective[4+2]- and [3 + 2]-cyclo-additions with stereoselectivity above 95%.

If you’re interested in learning more about 1975-50-4. The above is the message from the blog manager. Recommanded Product: 2-Methyl-3-nitrobenzoic acid.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 1975-50-4, Name is 2-Methyl-3-nitrobenzoic acid, formurla is C8H7NO4. In a document, author is Dettbarn, WD, introducing its new discovery. Application In Synthesis of 2-Methyl-3-nitrobenzoic acid.

Different role of carboxylesterases in toxicity and tolerance to paraoxon and DFP

The contribution of carboxylesterase (CarbE) to toxicity and tolerance to the organophosphorus anticholinesterases; (OP-antiChE) paraoxon (diethyl p-nitrophenyl phosphate) and DFP (diisopropylphosphorofluoridate) was investigated in rats. Daily injections (20 days) of paraoxon (0.33 mu mol/kg) or DFP (2.72 mu mol/kg) reduced AChE activity in brain to 29 or 16% and in diaphragm to 58 or 54%, respectively. The animals tolerated an accumulated 6-fold LD50 dose and survived an LD90 dose of carbachol, indicating tolerance to this cholinergic agonist. A single dose of paraoxon or DFP significantly reduced CarbE activity of plasma, lung and liver. After paraoxon, rapid recovery was seen of plasma and liver CarbE while recovery after DFP was much slower. Daily pretreatment with the CarbE inhibitors CBDP (2-[o-cresyl]-4H-1,2,3-benzodioxa- phosphorin-2-oxide) (7.22 mu mol/kg, s.c.) or iso-OMPA (tetraisopropylpyrophosphoramide) (8.76 mu mol/kg, i.p.), followed by paraoxon (0.33 mu mol/kg, s.c.) 30 min later, prevented the development of tolerance to paraoxon and potentiated its toxicity. Rats died on day four of the combined treatment. The CarbE inhibitors neither potentiated the DFP toxicity, nor prevented tolerance development to DFP. We conclude that rat plasma CarbE provides a significant protection against paraoxon toxicity because its rapid reactivation can reduce the toxicity of repeated paraoxon applications and thus contribute to tolerance development. This same mechanism does not apply to DFP toxicity, as inhibition of CarbE of plasma, liver and lung neither potentiated its toxicity, nor prevented tolerance development. These findings confirm previous observations that CarbE detoxification is of greater importance for highly toxic OP-antiChEs such as nerve agents and paraoxon than for less toxic ones such as DFP. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

If you are hungry for even more, make sure to check my other article about 1975-50-4, Application In Synthesis of 2-Methyl-3-nitrobenzoic acid.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 1975-50-4, Name is 2-Methyl-3-nitrobenzoic acid, molecular formula is C8H7NO4. In an article, author is Mironov, Vladimir F.,once mentioned of 1975-50-4, Quality Control of 2-Methyl-3-nitrobenzoic acid.

The reaction of 4-(1,3,2-benzodioxaphosphol-2-yloxy)-3-tert-butylpent-4-en-2-one with hexafluoroacetone

Catalytic (ZnCl2, Et3N) phosphorylation of tert-butylacetyl-acetone with 2-chloro-1,3,2-benzodioxaphosphole unexpectedly occurs with elimination of proton from the methyl group and leads to vinyloxyphosphole derivative, viz., 4-(1,3,2-benzodioxa-phosphol-2-yloxy)-3-tert-butylpent-4-en-2-one. Its reaction with hexafluoroacetone gives a cage phosphorane as a result of subsequent chemoselective[4+2]- and [3 + 2]-cyclo-additions with stereoselectivity above 95%.

If you¡¯re interested in learning more about 1975-50-4. The above is the message from the blog manager. Quality Control of 2-Methyl-3-nitrobenzoic acid.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In an article, author is WELL, M, once mentioned the application of 1975-50-4, COA of Formula: C8H7NO4, Name is 2-Methyl-3-nitrobenzoic acid, molecular formula is C8H7NO4, molecular weight is 181.1455, MDL number is MFCD00007160, category is benzodioxans. Now introduce a scientific discovery about this category.

SYNTHESIS AND NMR-SPECTROSCOPY OF PHOSPHORANES WITH 1,3,2-DIOXA-4,5-NAPHTHOPHOSPHOLE RING

The reaction of naphthalene-2,3-diol 1 with PCl3 was found to furnish the hydridophosphorane 3, with PCl5 the chlorophosphorane 4 was formed. The reaction of the fluorophosphoranes, RPF4 [R=F, (i)Pr, CH2SiMe3, CH2Cl, Ph] with the bis(trimethylsilyl) derivative of 1, 2 yielded the corresponding spirocyclic phosphoranes, 5-9 by cleavage of the Si-O bond and elimination of Me3SiF. The difluorophosphoranes, R2PF3 [R=Me, Ph] reacted with 2 to form the monocyclic phosphoranes, 10 and 11, where the fluorine atom occupies an axial position at trigonal-bipyramidal (TBP) phosphorus- The structure of compound 11 was confirmed by single crystal X-ray analysis of its dichloromethane hemisolvate at -95-degrees-C. The geometry at phosphorus is trigonal-bipyramidal. whereby the naphthalenedioxy ligand spans an axial and an equatorial site. Me2PF3 reacted with tetrakis(1,2,4.5-trimethylsiloxy)benzene to form the bifunctional benzodioxa-lambda5-phosphole, 12.

Interested yet? Read on for other articles about 1975-50-4, you can contact me at any time and look forward to more communication. COA of Formula: C8H7NO4.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.1975-50-4, Name is 2-Methyl-3-nitrobenzoic acid, SMILES is CC1=C(C=CC=C1N(=O)=O)C(O)=O, belongs to benzodioxans compound. In a document, author is LUNDMARK, S, introduce the new discover, Product Details of 1975-50-4.

KINETICS, MECHANISMS, AND SYNTHESIS STUDIES OF RING-OPENING-CLOSING ALTERNATING COPOLYMERIZATION

The present paper describes the ring-opening-closing alternating copolymerization of cyclic phosphonites (2-phenyl-1,3,2-dioxaphospholane (1a), 2-phenyl-1,3,2-dioxaphosphorinane(1b), 2-phenyl-1,3,2-dioxaphosphepane(1c), and 2-phenyl-4H-1,3,2-benzodioxa phosphorin-4-one(1d) with muconic acid(2a), succinaldehyde(2b), glutaraldehyde(2c), adipinaldehyde(2d), o-phthalaldehyde(2e), acrylic anhydride(2f), methacrylic anhydride(2g), N-methyl diacrylamide(2h), and N-methyldimethacrylamide(2i). The reaction of a 1:1 monomer feed ratio, explained by a mechanism of propagation via zwitterion intermediates, proceeds without any added catalyst to give an alternating copolymer 3 involving ring-opening of 1 and ring-closing of 2. The structure of copolymer 3 was determined by H-1, C-13 NMR, P-31 NMR and IR spectroscopies as well as elemental analysis.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1975-50-4 is helpful to your research. Product Details of 1975-50-4.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Electric Literature of 1975-50-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 1975-50-4, Name is 2-Methyl-3-nitrobenzoic acid, SMILES is CC1=C(C=CC=C1N(=O)=O)C(O)=O, belongs to benzodioxans compound. In a article, author is Bulut, Volkan Numan, introduce new discover of the category.

Selective Solid Phase Extraction for Separation and Preconcentration of Palladium from Gold Ore and Anode Slime after Complexation with a N4O2 Mixed Donor Ligand Derivative

A selective and sensitive method for the preconcentration, separation, and determination of palladium with flame atomic absorption spectrometry using 4,15-bis[(4-methylphenyl)sulfonyl]-20,21-dinitro-2,3,4,5,6,7,9,10,12,13,14,15,16,17-tetradecahydro- 8,11-ethano-1,18,4,8,11,15-benzodioxa tetraaza cycloicosine (TNACIN) on XAD-2010 was developed. TNACIN-Pd(II) complex formed acidic aqueous solution (0.075-0.100 M HNO3) was accumulated on XAD-2010 and then eluted with 1 M HCl in acetone. The effects of some analytical parameters including pH, TNACIN amount, sample volume, eluent type, and concentration, sample flow rate and matrix ions were studied for optimization of the method. Detection limit and precision were calculated for Pd(II). This method was also verified with CRM and internal standard, and satisfactory results were obtained.

Electric Literature of 1975-50-4, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 1975-50-4 is helpful to your research.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In an article, author is Ali, HM, once mentioned the application of 1975-50-4, Recommanded Product: 1975-50-4, Name is 2-Methyl-3-nitrobenzoic acid, molecular formula is C8H7NO4, molecular weight is 181.1455, MDL number is MFCD00007160, category is benzodioxans. Now introduce a scientific discovery about this category.

Selectivity, acetylcholinesterase inhibition kinetics, and quantitative structure-activity relationships of a series of N-(2-oxido-1,3,2-benzodioxa-phosphol-2-yl) amino acid ethyl or diethyl esters

The inhibitory effects of a recently introduced series of the titled compounds on insect and mammalian acetylcholinesterase (AChE) activity were examined, where the median inhibition concentration (I-50) and the inhibition kinetic parameters, bimolecular inhibition rate constant (k(i)), affinity constant (K-a), and phosphorylation rate constant (k(p)), were determined for each compound. Results indicated that all examined dioxaphospholenes had less inhibitory effects on mammalian AChE than fenitrothion, a commercial pesticide with moderate mammalian toxicity. The highest selectivity was obtained with compounds containing glutamic and leucine moieties (2.70 and 2.18, respectively) while selectivity of fenitrothion was 0.93. The low inhibitory effects of the examined dioxaphospholenes on mammalian AChE were attributed to their low phosphorylation rates(k(p) < 2.2 min(-1)) compared to that of fenitrothion (k(p) = 4.84 min(-1)). QSAR equations indicated that the inhibition process is controlled mainly by both the phosphorylation rate (direct effect) and the affinity of compounds toward the enzyme (inverse effect). Although the compounds' hydrophobicity had no effects on the inhibition process, it affects the compounds' toxicity since it affects the ability of compounds to penetrate insects to reach the enzyme active site. (c) 2005 Elsevier Inc. All rights reserved. If you are interested in 1975-50-4, you can contact me at any time and look forward to more communication. Recommanded Product: 1975-50-4.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Synthetic Route of 1975-50-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 1975-50-4, Name is 2-Methyl-3-nitrobenzoic acid, SMILES is CC1=C(C=CC=C1N(=O)=O)C(O)=O, belongs to benzodioxans compound. In a article, author is Bilgin, Ahmet, introduce new discover of the category.

Novel porphyrazines containing peripherally functionalized macrocyclic (N2O2, N2S2) units: Synthesis and characterization

Novel maleonitrile moieties were synthesized by cyclization of 2,3-bis[(2-pyridylmethyl)amino]-2(Z)-butene-1,4-dinitrile with 1,2-bis(2-iodoethoxy)-4-nitrobenzene or o-xylyenebis(1-chloro-3-thiapropane) under conditions of high dilution. A series of novel, free-base, magnesium and zinc porphyrazines bearing macrocyclic substituents in peripheral positions were prepared via Linstead macrocyclization reactions of different maleonitrile derivatives, 12-nitro-4,7-bis(pyridin-2-ylmethyl)-2,3,4,7,8,9-hexahydro-1,10,4,7-benzodioxa-diaza-cyclododecine-5,6-dicarbonitrile or 5,8-bis(pyridin-2-ylmethyl)-1,3,4,5,8, 9,10,12-octa-hydro-2,11,5,8-benzodi-thiadiazacyclo-tetradecine-6,7-dicarbonitrile and the corresponding divalent metal salts. Pentanuclear copper(II) complexes were also prepared from the corresponding zinc(II) porphyrazine derivatives. The compounds were characterized by a combination of elemental analysis, FT-IR, UV-vis, H-1 NMR, C-13 NMR and MS spectral data. (c) 2008 Elsevier Ltd. All rights reserved.

Synthetic Route of 1975-50-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 1975-50-4.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 1975-50-4, Name is 2-Methyl-3-nitrobenzoic acid, molecular formula is C8H7NO4. In an article, author is Mironov, Vladimir F.,once mentioned of 1975-50-4, Application In Synthesis of 2-Methyl-3-nitrobenzoic acid.

The reaction of 4-(1,3,2-benzodioxaphosphol-2-yloxy)-3-tert-butylpent-4-en-2-one with hexafluoroacetone

Catalytic (ZnCl2, Et3N) phosphorylation of tert-butylacetyl-acetone with 2-chloro-1,3,2-benzodioxaphosphole unexpectedly occurs with elimination of proton from the methyl group and leads to vinyloxyphosphole derivative, viz., 4-(1,3,2-benzodioxa-phosphol-2-yloxy)-3-tert-butylpent-4-en-2-one. Its reaction with hexafluoroacetone gives a cage phosphorane as a result of subsequent chemoselective[4+2]- and [3 + 2]-cyclo-additions with stereoselectivity above 95%.

If you¡¯re interested in learning more about 1975-50-4. The above is the message from the blog manager. Application In Synthesis of 2-Methyl-3-nitrobenzoic acid.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 1975-50-4, Name is 2-Methyl-3-nitrobenzoic acid, formurla is C8H7NO4. In a document, author is Dettbarn, WD, introducing its new discovery. Quality Control of 2-Methyl-3-nitrobenzoic acid.

Different role of carboxylesterases in toxicity and tolerance to paraoxon and DFP

The contribution of carboxylesterase (CarbE) to toxicity and tolerance to the organophosphorus anticholinesterases; (OP-antiChE) paraoxon (diethyl p-nitrophenyl phosphate) and DFP (diisopropylphosphorofluoridate) was investigated in rats. Daily injections (20 days) of paraoxon (0.33 mu mol/kg) or DFP (2.72 mu mol/kg) reduced AChE activity in brain to 29 or 16% and in diaphragm to 58 or 54%, respectively. The animals tolerated an accumulated 6-fold LD50 dose and survived an LD90 dose of carbachol, indicating tolerance to this cholinergic agonist. A single dose of paraoxon or DFP significantly reduced CarbE activity of plasma, lung and liver. After paraoxon, rapid recovery was seen of plasma and liver CarbE while recovery after DFP was much slower. Daily pretreatment with the CarbE inhibitors CBDP (2-[o-cresyl]-4H-1,2,3-benzodioxa- phosphorin-2-oxide) (7.22 mu mol/kg, s.c.) or iso-OMPA (tetraisopropylpyrophosphoramide) (8.76 mu mol/kg, i.p.), followed by paraoxon (0.33 mu mol/kg, s.c.) 30 min later, prevented the development of tolerance to paraoxon and potentiated its toxicity. Rats died on day four of the combined treatment. The CarbE inhibitors neither potentiated the DFP toxicity, nor prevented tolerance development to DFP. We conclude that rat plasma CarbE provides a significant protection against paraoxon toxicity because its rapid reactivation can reduce the toxicity of repeated paraoxon applications and thus contribute to tolerance development. This same mechanism does not apply to DFP toxicity, as inhibition of CarbE of plasma, liver and lung neither potentiated its toxicity, nor prevented tolerance development. These findings confirm previous observations that CarbE detoxification is of greater importance for highly toxic OP-antiChEs such as nerve agents and paraoxon than for less toxic ones such as DFP. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

If you are hungry for even more, make sure to check my other article about 1975-50-4, Quality Control of 2-Methyl-3-nitrobenzoic acid.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem