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Biogenic synthesis of Fe2O3@SiO2 nanoparticles for ipso-hydroxylation of boronic acid in water

Here, biogenic synthesis of Fe2O3@SiO2 nanoparticles using fruit extract of Zanthoxylum rhetsa is reported. The SiO2 nanoparticles was synthesized using paddy straw which is a byproduct obtained in cultivation of rice. The composite was characterised by spectroscopic method like XRD, SEM, TEM and EDX analysis. The ipso-hydroxylation reactions were carried out with excellent yield within a moderate time period with mild reaction condition in all cases. Therefore, this approach may be considered as simple, easy, cheap and greener, environment friendly protocol for ipso-hydroxylation of arylboronic acids at 50 C temperature.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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Regioselective aminomethylations of bicyclic phenols

The regioselectivity in the aminomethylations (the Mannich reaction) of bicyclic phenols has been studied. Highly regioselective Mannich reactions enable easy synthetic access to novel bicyclic dialkylaminomethylphenols under very mild reaction conditions.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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SYNTHESIS OF 6,7-ETHYLENEDIOXY-2,2-DIMETHYL-3-CHROMENE

The synthesis of the title compound, a precocene analog, obtained for investigation on its biological activity, is described.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 10288-72-9, name is 6-Hydroxy-1,4-benzodioxane, introducing its new discovery. Product Details of 10288-72-9

Discovery of potent, orally available vanilloid receptor-1 antagonists. Structure-activity relationship of N-aryl cinnamides

The vanilloid receptor-1 (TRPV1 or VR1) is a member of the transient receptor potential (TRP) family of ion channels and plays a role in regulating the function of sensory nerves. A growing body of evidence demonstrates the therapeutic potential of TRPV1 modulators, particularly in the management of pain. As a result of our screening efforts, we identified (E)-3-(4-tert- butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide (1), an antagonist that blocks the capsaicin-induced and pH-induced uptake of 45Ca2+ in TRPV1-expressing Chinese hamster ovary cells with IC50 values of 17 ¡À 5 and 150 ¡À 80 nM, respectively. In this report, we describe the synthesis and structure-activity relationship of a series of N-aryl cinnamides, the most potent of which (49a and 49b) exhibit good oral bioavailability in rats (Foral = 39% and 17%, respectively).

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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Electric Literature of 10288-72-9, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 10288-72-9, molcular formula is C8H8O3, introducing its new discovery.

PYRIMIDINE DERIVATIVES AS PGE2 RECEPTOR MODULATORS

The present invention relates to pyrimidine derivatives of formula (I) wherein (R1)n, R3, R4a, R4b, R5a, R5b and Ar1 are as described in the description and their use in the treatment of cancer by modulating an immune response comprising a reactivation of the immune system in the tumor. The invention further relates to novel benzofurane and benzothiophene derivatives of formula (II) and their use as pharmaceuticals, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 10288-72-9, name is 6-Hydroxy-1,4-benzodioxane, introducing its new discovery. Application In Synthesis of 6-Hydroxy-1,4-benzodioxane

Syntheses of 2-Substituted 6/7-Methoxy-1,4-benzodioxan-7/6-carbaldehydes

Five 2-substituted 6/7-methoxy-1,4-benzodioxan-7/6-carbaldehydes and 6-methoxy-1,4-benzodioxan-7-carbaldehyde available for the syntheses of insecticidal neolignan analogs were prepared from 4/3-benzyloxy-3/4-hydroxybenzaldehydes and 1,4-benzodioxan-6-carbaldehyde, respectively.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Extracurricular laboratory:new discovery of 10288-72-9

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10288-72-9, Name is 6-Hydroxy-1,4-benzodioxane, belongs to benzodioxans compound, is a common compound. Quality Control of 6-Hydroxy-1,4-benzodioxaneIn an article, once mentioned the new application about 10288-72-9.

New Alkoxylated Dibenzo<1,4>dichalcogenines as Donors for Low-dimensional Materials: Electrochemistry and Cation-radical Salts

The synthesis of new alkoxylated dibenzo<1,4>dichalcogenines (3a-c), (3e-f), (3h), (4a-h), and (5a) is presented.The first cyclovoltammetric half-wave potentials of these compounds range from 0.62 to 1.06 V vs. standard calomel electrode (s.c.e.).Cation radical salts of several different stoicheiometries have been prepared from the new donors.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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Acylbenzoxazines for enhancing synaptic response

Compounds based on the benzoxazine ring system that are remarkably more potent than corresponding benzoyl piperidines for enhancing synaptic responses mediated by AMPA receptors are disclosed, as are methods for the preparation thereof, and methods for their use for treatment of subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number of excitatory synapses or in the number of AMPA receptors. The invention compounds can also be used for the treatment of non-impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors and for improving memory encoding.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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Convenient synthesis of 5-substituted-6-methoxy or 6-hydroxy-2,3-dihydro-1,4-benzodioxins via lithiated intermediates

The 6-methoxy and 6-tetrahydropyranyloxy-2,3-dihydro-1,4-benzodioxins can be lithiated at the 5-position to give intermediate lithio derivatives which react with various electrophiles to afford, after hydrolysis, 5-substituted-6-methoxy and 6-hydroy-2,3-dihydro-1,4-benzodioxins.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Brief introduction of 6-Hydroxy-1,4-benzodioxane

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VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS

Pyrimidine ethers and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem