Category: 100-19-6

Recommanded Product: 100-19-6. Authors Ghosh, R; Jana, NC; Panda, S; Bagh, B in AMER CHEMICAL SOC published article about in [Ghosh, Rahul; Jana, Narayan Ch; Panda, Surajit; Bagh, Bidraha] HBNI, Natl Inst Sci Educ & Res NISER, Sch Chem Sci, Bhubaneswar 752050, Odisha, India in 2021, Cited 111. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Coordination of 1,4-disubstituted 1,2,3-triazoles L-1 and L-2 with [(p-cymene)RuCl2](2) followed by dehydrochlorination in the presence of a base resulted in the formation of complexes 1 and 2, respectively. Both were tested for the transfer hydrogenation of aldehydes and ketones in air using ecologically benign and cheap ethanol as the hydrogen source in the presence of a catalytic amount of a base. Air-stable complex 1 was proved to be an active catalyst for the transfer hydrogenation of a wide variety of aromatic and aliphatic aldehydes and ketones bearing various functionalities. Catalyst 1 was also effective for the transfer hydrogenation of carbonyls using the simplest primary alcohol, methanol, under aerobic conditions. Under the present catalytic protocol, labile or reducible functionalities such as nitro, cyano, and ester groups were tolerated. Good selectivity was also observed for acyclic alpha,beta-unsaturated carbonyls. However, this catalytic protocol was not selective for 2-cyclohexen-1-one as both alkene and keto moieties were reduced. The transfer hydrogenations are believed to proceed via a ruthenium-hydride intermediate. Finally, transfer hydrogenation of acetophenone using isopropanol as a commonly used hydrogen source was also performed and the sustainable and green credentials of these catalytic protocols utilizing methanol, ethanol, and isopropanol were compared with the help of the CHEM21 green metrics toolkit.

Recommanded Product: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Ghosh, R; Jana, NC; Panda, S; Bagh, B or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2020.0 BIOORG CHEM published article about DIHYDROFOLATE-REDUCTASE INHIBITORS; ANTIOPPORTUNISTIC INFECTION AGENTS; DUAL THYMIDYLATE SYNTHASE; DERIVATIVES; ANTITUMOR; POTENT; DISCOVERY; DESIGN in [Wang, Fu-Cheng; Cao, Sheng-Li; Li, Hong-Yun; Yuan, Xiao-Li; Zhang, Ting-Ting] Capital Normal Univ, Dept Chem, Beijing 100048, Peoples R China; [Wang, Fu-Cheng; Cao, Sheng-Li; Li, Hong-Yun; Yuan, Xiao-Li; Zhang, Ting-Ting; Wang, Hailong; Li, Jing] Capital Normal Univ, Beijing Key Lab DNA Damage Response, Beijing 100048, Peoples R China; [Peng, Bin; Shi, Ruifeng; Li, Zhuqing; Liao, Ji; Xu, Xingzhi] Shenzhen Univ, Guangdong Key Lab Genome Stabil & Dis Prevent, Sch Med, Shenzhen 518060, Guangdong, Peoples R China; [Peng, Bin; Shi, Ruifeng; Li, Zhuqing; Liao, Ji; Xu, Xingzhi] Shenzhen Univ, Carson Int Canc Ctr, Sch Med, Shenzhen 518060, Guangdong, Peoples R China; [Peng, Bin; Shi, Ruifeng; Li, Zhuqing; Liao, Ji; Xu, Xingzhi] Shenzhen Univ, Marshall Lab Biomed Engn, Sch Med, Shenzhen 518060, Guangdong, Peoples R China; [Wang, Hailong; Li, Jing] Capital Normal Univ, Coll Life Sci, Beijing 100048, Peoples R China in 2020.0, Cited 31.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Recommanded Product: 1-(4-Nitrophenyl)ethanone

Many natural or synthetic chalcones have potential anti-tumor activity. Here, we synthesized two series of chalcone analogues containing a thieno [2,3-cflpyrimidin-2-y] group and evaluated for their cytotoxic activity towards cultured human lung cancer A549 and colorectal HCT-116 cells. Among them, compound 8d was the most cytotoxic against HCT-116 cells, with an IC50 value of 2.65 mu M. Analyses of the phenotypic changes induced by this compound found a dose-dependent accumulation of HCT-116 cells in sub-G1 phase, indicating that compound 8d might induce apoptosis. Furthermore, we found that 8d triggered mitochondrial membrane potential depolarization, promoted reactive oxygen species formation in HCT-116 cells, and increased the percentage of early and late apoptotic cells. Finally, immunoblotting indicated that 8d increased PARP-1 and caspases 3, 7 and 9 cleavage. These data suggest that compound 8d induces apoptosis via the mitochondrial death pathway.

Recommanded Product: 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Wang, FC; Peng, B; Cao, SL; Li, HY; Yuan, XL; Zhang, TT; Shi, RF; Li, ZQ; Liao, J; Wang, HL; Li, J; Xu, XZ or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Mehiaoui, N; Kibou, Z; Gallavardin, T; Leleu, S; Franck, X; Mendes, RF; Paz, FAA; Silva, AMS; Choukchou-Braham, N in SPRINGER published article about 2-PYRIDONE DERIVATIVES; DESIGN; AGENTS in [Mehiaoui, Nawel; Kibou, Zahira; Choukchou-Braham, Noureddine] Univ Tlemcen, Lab Catalyse & Synth Chim Organ, Fac Sci, BP 119, Tilimsen 13000, Algeria; [Kibou, Zahira] Ctr Univ Ain Temouchent, Inst Sci, BP 284, Ain Temouchent 46000, Algeria; [Gallavardin, Thibault; Leleu, Stephane; Franck, Xavier] Normandie Univ, CNRS, UNIROUEN, INSA Rouen,COBRA,UMR6014, F-76000 Rouen, France; [Gallavardin, Thibault; Leleu, Stephane; Franck, Xavier] Normandie Univ, CNRS, UNIROUEN, INSA Rouen,FR 3038, F-76000 Rouen, France; [Mendes, Ricardo F.; Paz, Filipe A. Almeida] Univ Aveiro, Dept Chem, CICECO Aveiro Inst Mat, P-3810193 Aveiro, Portugal; [Silva, Artur M. S.] Univ Aveiro, Dept Chem, QOPNA, P-3810193 Aveiro, Portugal; [Silva, Artur M. S.] Univ Aveiro, LAQV REQUIMTE, P-3810193 Aveiro, Portugal in 2021.0, Cited 44.0. Recommanded Product: 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Novel substituted bis-(3-cyano-2-pyridone) derivatives were prepared via a powerful method using enaminonitriles push-pull dienes as key building blocks. The synthesis was performed in three steps from easily accessible starting materials in good yields. All target products were structurally elucidated by spectroscopic data. The reaction mechanism for formation of bis (3-cyano-2-pyridone) derivatives was proposed. The structures of enaminonitriles 3a and bis-pyridones 4c were confirmed by single-crystal X-ray diffraction. The florescent study of some bis (3-cyano-2-pyridones) derivatives was reported. [GRAPHICS]

Recommanded Product: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Mehiaoui, N; Kibou, Z; Gallavardin, T; Leleu, S; Franck, X; Mendes, RF; Paz, FAA; Silva, AMS; Choukchou-Braham, N or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Quality Control of 1-(4-Nitrophenyl)ethanone. Wang, HS; Zhao, WX; Du, J; Wei, FY; Chen, Q; Wang, XM in [Wang, Hongshe; Zhao, Weixing; Du, Juan; Wei, Fenyan; Chen, Qi; Wang, Xiaomei] Baoji Univ Arts & Sci, Coll Chem & Chem Engn, Baoji 721013, Peoples R China published Cationic organotin cluster [t-Bu2Sn(OH)(H2O)](2)(2+)2OTf(-)-catalyzed one-pot three-component syntheses of 5-substituted 1H-tetrazoles and 2,4,6-triarylpyridines in water in 2019.0, Cited 46.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

The cationic organotin cluster [t-Bu2Sn(OH)(H2O)](2)(2+)2OTf(-) is easy to prepare and stable in air. The catalytic activity of [t-Bu2Sn(OH)(H2O)](2)(2+)2OTf(-) as a neutral organotin Lewis acid catalyst is probed through the one-pot three-component syntheses of 5-substituted 1H-tetrazoles from aldehydes, hydroxylamine hydrochloride and sodium azide, and of 2,4,6-triarylpyridines from aromatic aldehydes, substituted acetophenones and ammonium acetate. The reactions proceed well in the presence of 1 mol% of [t-Bu2Sn(OH)(H2O)](2)(2+)2OTf(-) in water and provide the corresponding 5-substituted 1H-tetrazoles and 2,4,6-triarylpyridines in good to excellent yields. The method reported has several advantages such as the catalyst being neutral, low catalyst loading and use of water as a green solvent.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Wang, HS; Zhao, WX; Du, J; Wei, FY; Chen, Q; Wang, XM or concate me.. Quality Control of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Synthesis of new isoquinoline-base-oxadiazole derivatives as potent inhibitors of thymidine phosphorylase and molecular docking study WOS:000494258500035 published article about ALPHA-GLUCOSIDASE SYNTHESIS; IN-VITRO EVALUATION; CELL GROWTH-FACTOR; BETA-GLUCURONIDASE; BIOLOGICAL EVALUATION; ANALOGS; ACETYLCHOLINESTERASE; THIOSEMICARBAZIDES in [Zaman, Khalid; Rahim, Fazal] Hazara Univ, Dept Chem, Mansehra 21300, Khyber Pakhtunk, Pakistan; [Taha, Muhammad] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat, Dept Clin Pharm, POB 1982, Dammam 31441, Saudi Arabia; [Wadood, Abdul] Abdul Wali Khan Univ Mardan, Dept Biochem, Mardan 23200, Pakistan; [Shah, Syed Adnan Ali] Univ Teknol MARA, Fac Pharm, Cawangan Selangor Kampus, Selangor 42300, DE, Malaysia; [Shah, Syed Adnan Ali] Univ Teknol MARA, Atta Ur Rahman Inst Nat Prod Discovery AuRIns, Cawangan Selangor Kampus PuncakAlam, Selangor 42300, DE, Malaysia; [Ahmed, Qamar Uddin] Int Islamic Univ Malaysia, Kulliyyah Pharm, Dept Pharmaceut Chem, Pahang Dm 25200, Kuantan, Malaysia; [Zakaria, Zainul Amiruddin] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Biomed Sci, Serdang 43400, Selangor, Malaysia; [Zakaria, Zainul Amiruddin] Univ Putra Malaysia, Halal Inst Res Inst, Serdang 43400, Selangor, Malaysia in 2019.0, Cited 48.0. Recommanded Product: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Here in this study regarding the over expression of TP, which causes some physical, mental and socio problems like psoriasis, chronic inflammatory disease, tumor angiogenesis and rheumatoid arthritis etc. By this consideration, the inhibition of this enzyme is vital to secure life from serious threats. In connection with this, we have synthesized twenty derivatives of isoquinoline bearing oxadiazole (1-20), characterized through different spectroscopic techniques such as HREI-MS, H-1-NMR and C-13-NMR and evaluated for thymidine phosphorylase inhibition. All analogues showed outstanding inhibitory potential ranging in between 1.10 +/- 0.05 to 54.60 +/- 1.50 mu M. 7-Deazaxanthine (IC50 = 38.68 +/- 1.12 mu M) was used as a positive control. Through limited structure activity relationships study, it has been observed that the difference in inhibitory activities of screened analogs are mainly affected by different substitutions on phenyl ring. The effective binding interactions of the most active analogs were confirmed through docking study.

Recommanded Product: 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Zaman, K; Rahim, F; Taha, M; Wadood, A; Shah, SAA; Ahmed, QU; Zakaria, ZA or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Category: benzodioxans. Authors Song, T; Zhou, X; Wang, XX; Xiao, JL; Yang, Y in ROYAL SOC CHEMISTRY published article about in [Song, Tao; Zhou, Xin; Wang, Xiaoxue; Yang, Yong] Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, 189 Songling Rd, Qingdao 266101, Peoples R China; [Xiao, Jianliang] Univ Liverpool, Dept Chem, Crown St, Liverpool L69 7ZD, Merseyside, England; [Song, Tao; Zhou, Xin; Wang, Xiaoxue; Yang, Yong] Shandong Energy Inst, Qingdao 266101, Peoples R China in 2021.0, Cited 66.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A new methodology for the synthesis of alpha-diketones was reported via a one-pot cascade process from aldehydes and ketones catalyzed by a bifunctional iron nanocomposite using H2O2 as a green oxidant in water. The one-pot strategy showed excellent catalytic stability, comprehensive suitability of substrates and important practical utility for directly synthesizing biologically active and medicinally valuable N-heterocycles via an intermittent process.

Category: benzodioxans. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Song, T; Zhou, X; Wang, XX; Xiao, JL; Yang, Y or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Li, W; Artz, J; Broicher, C; Junge, K; Hartmann, H; Besmehn, A; Palkovits, R; Beller, M in ROYAL SOC CHEMISTRY published article about ORDERED MESOPOROUS CARBON; FISCHER-TROPSCH SYNTHESIS; CHEMOSELECTIVE HYDROGENATION; FUNCTIONALIZED NITROARENES; METAL NANOPARTICLES; SIZE; FRAMEWORKS; OXIDATION; STRATEGY; SCIENCE in [Li, Wu; Junge, Kathrin; Beller, Matthias] Univ Rostock, Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany; [Artz, Jens; Broicher, Cornelia; Palkovits, Regina] Rhein Westfal TH Aachen, Inst Tech & Makromol Chem, Worringerweg 2, D-52074 Aachen, Germany; [Hartmann, Heinrich; Besmehn, Astrid] Forschungszentrum Julich, Wilhelm Johnen Str, D-5248 Julich, Germany in 2019, Cited 51. SDS of cas: 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

The development of improved catalysts for highly selective hydrogenation of nitroarenes is described. For this purpose Co nanoparticles were supported on ordered mesoporous carbon CMK-3 and characterized in detail. The optimal CMK-3-CoPc catalyst exhibits excellent hydrogenation activity for several (hetero)aromatic nitro compounds and yielded the corresponding anilines under mild conditions (40 degrees C, 20 bar H-2).

SDS of cas: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Li, W; Artz, J; Broicher, C; Junge, K; Hartmann, H; Besmehn, A; Palkovits, R; Beller, M or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Category: benzodioxans. Recently I am researching about BIOLOGICAL EVALUATION; IN-VITRO; DERIVATIVES; ANTICANCER; MECHANISM; POISONS; SERIES, Saw an article supported by the National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81502911]; Municipal Program for Science and Technology of Guangzhou [202002030212]. Published in MDPI in BASEL ,Authors: Zhou, W; Zhang, WJ; Peng, Y; Jiang, ZH; Zhang, LY; Du, ZY. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

Chemical diversification of type II topoisomerase (Topo II) inhibitors remains indispensable to extend their anti-tumor therapeutic values which are limited by their side effects. Herein, we designed and synthesized a novel series of benzimidazole-chalcone hybrids (BCHs). These BCHs showed good inhibitory effect in the Topo II mediated DNA relaxation assay and anti-proliferative effect in 4 tumor cell lines.4dand4nwere the most potent, with IC(50)values less than 5 mu M, superior to etoposide. Mechanistic studies indicated that the BCHs functioned as non-intercalative Topo II catalytic inhibitors. Moreover,4dand4ndemonstrated versatile properties against tumors, including inhibition on the colony formation and cell migration, and promotion of apoptosis of A549 cells. The structure-activity relationship and molecular docking analysis suggested possible contribution of the chalcone motif to the Topo II inhibitory and anti-proliferative potency. These results indicated that4dand4ncould be promising lead compounds for further anti-tumor drug research.

Category: benzodioxans. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Zhou, W; Zhang, WJ; Peng, Y; Jiang, ZH; Zhang, LY; Du, ZY or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Category: benzodioxans. Authors Srilaxmi, D; Sreenivasulu, R; Mak, KK; Pichika, MR; Jadav, SS; Ahsan, MJ; Rao, MVB in ELSEVIER published article about in [Srilaxmi, Dandamudi; Rao, Mandava Venkata Basaveswara] Krishna Univ, Dept Chem, Machilipatnam 521001, Andhra Pradesh, India; [Sreenivasulu, Reddymasu] Jawaharlal Nehru Technol Univ, Univ Coll Engn Autonomous, Dept Chem, Kakinada 533003, Andhra Pradesh, India; [Mak, Kit-Kay; Pichika, Mallikarjuna Rao] Int Med Univ, Sch Pharm, Pharmaceut Chem Dept, 126,Jalan Jalil Perkasa 19 Bukit Jalil, Kuala Lumpur 57000, Malaysia; [Jadav, Surender Singh] Vishnu Inst Pharmaceut Educ & Res VIPER, Medak 502313, Telangana, India; [Ahsan, Mohamed Jawed] Maharishi Arvind Coll Pharm, Dept Pharmaceut Chem, Jaipur 302039, Rajasthan, India in 2021.0, Cited 69.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A series of novel chalcone derivatives pyrido[4,3-b]pyrazin-5(6H)-one (10a-j) were designed, synthesized and their structures were confirmed by H-1 NMR, C-13 NMR and mass spectral data. Further, all derivatives were tested for their anticancer activities against five human cancer cell lines such as MCF-7 (breast cancer), A-549 (lung cancer), Colo-205 (colon cancer), A2780 (ovarian cancer) and DU-145 (prostate cancer) by employing MIT assay. The clinically used drug etoposide was used as standard reference and the anticancer activity was expressed as the IC50 in mu M. Among the ten compounds examined compounds, 10b, 10c, 10d, 10h, and 10i possessed more promising anticancer activity. A molecular docking study implying ATR kinase was carried out to observe the binding mode of chalcone derivatives pyrido[4,3-b]pyrazin-5(6H)-one (10a-j) on the active site of ATR kinase. The most promising compound, 10h showed pi – pi stacking interaction of trimethoxy phenyl and pyridone moiety with the residue Trp850, while the carbonyl (alpha,beta-unsaturated carbonyl) and methoxy functions showed H-bond interaction with the residue Ser773 and Thr856 respectively. (C) 2020 Elsevier B.V. All rights reserved.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Srilaxmi, D; Sreenivasulu, R; Mak, KK; Pichika, MR; Jadav, SS; Ahsan, MJ; Rao, MVB or concate me.. Category: benzodioxans

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019.0 RUSS J ORG CHEM+ published article about ASSISTED SYNTHESIS; DERIVATIVES; FLAVONOIDS; CHALCONE in [Pujari, V. K.; Maroju, S.] NewAge Life Sci Pvt Ltd, IDA Phase 2, Hyderabad, Telangana, India; [Vinnakota, S.] ICFAI Fdn Higher Educ, Fac Sci & Technol, Dept Chem, Hyderabad, Telangana, India; [Kakarla, R. K.] CMR Inst Technol, Dept Chem, Hyderabad, Telangana, India; [Ganesh, A.] Hypersynth Life Sci, IDA Phase 2, Hyderabad, Telangana, India in 2019.0, Cited 15.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Recommanded Product: 100-19-6

A convenient one-pot, three-component, and solvent-free procedure for the preparation of substituted (E)-1-phenyl-3-[2-(piperidin-1-yl)quinolin-3-yl]prop-2-en-1-ones, which has made a significant improvement of previously reported methods, has been developed. The reaction of chloro aldehydes, ketones, and piperidine under microwave irradiation afforded the corresponding piperidine-substituted chalcone derivatives in high yields in shorter reaction times. All the synthesized compounds were characterized by IR and H-1 and C-13 NMR spectroscopy, and mass spectroscopy.

Recommanded Product: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Pujari, VK; Vinnakota, S; Kakarla, RK; Maroju, S; Ganesh, A or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem