As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO16,mainly used in chemical industry, its synthesis route is as follows.,4442-54-0
1.80 g (10 mmol) of 1,4-benzodioxane-6-carboxylic acid was dissolved in 50 ml of dichloromethane, and 3.8 g (20 mmol) 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride, 2.7 g (20 mmol) of 1-hydroxybenzotriazole, After reaction at room temperature for 1 h, 3.3 mL (20 mmol) N, N-diisopropylethylamine, 0.122 g (1 mmol) of 4-dimethylaminopyridine, 2.03 g (10 mmol) of 4-nitrophenethylamine hydrochloride was added and reacted at room temperature for 24 h. The appropriate amount of water was added, extracted with ethyl acetate, washed with saturated brine, and the organic phase was concentrated. ), And the residue was purified by silica gel column chromatography (eluent: ethyl acetate: petroleum ether = 1: 25, v / v) to give a white solid (compound represented by formula II-1) in 81percent yield
With the synthetic route has been constantly updated, we look forward to future research findings about 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid,belong benzodioxans compound
Reference£º
Patent; East China University of Science and Technology; Zhu Jin; Huang Jin; Chen Wenhua; Yao Xue; Ling Dazheng; Wang Manjiong; Jiang Hualiang; Li Jian; (21 pag.)CN106938997; (2017); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem