With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4442-54-0,2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid,as a common compound, the synthetic route is as follows.
Oxalyl chloride (10 mL) is added to 2,3-dihydro-benzo[1 ,4]dioxine-6-carboxylic acid (14.9 g) dissolved in dichloromethane (100 mL). After the addition of N,N-dimethylformamide (0.5 ml_), the mixture is stirred at room temperature overnight and then concentrated. The residue is taken up in dichloromethane (100 ml.) and added to a mixture of nortropinone hydrochloride (10.0 g) and potassium carbonate (12.0 g) in dichloromethane (50 ml_). Then, pyridine (18 ml.) is added and the mixture is stirred at room temperature overnight. The mixture is concentrated and the residue is taken up in dichloromethane and washed with 1 M aqueous hydrochloric acid, 1 M aqueous NaOH solution, and brine. After drying (Na2SO4), the solvent is removed under reduced pressure to yield the title compound. Yield: 17.3 g (75percent of theory) Mass spectrum (ESI+): m/z = 288 [M+H]+
The synthetic route of 4442-54-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ECKHARDT, Matthias; HAMILTON, Bradford, S.; HIMMELSBACH, Frank; PETERS, Stefan; WO2010/23161; (2010); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem