Brief introduction of 4442-53-9

The synthetic route of 4442-53-9 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4442-53-9,2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid,as a common compound, the synthetic route is as follows.,4442-53-9

Synthesis of 7-(chlorosulfonyl)-2,3-dihydrobenzo[b] [l,4]dioxine-5-carboxylic acid (XIII):To a stirred solution of 2,3-dihydrobenzo[b][l,4]dioxine-5-carboxylic acid XII (0.5 g, 2.77 mmol) was added chlorosulphonic acid (1.2 ml, 16.6 mmol) at 0¡ãC under nitrogen atmosphere and the resulting mixture was heated at 70¡ãC for 3 h. After completion of reaction, the reaction mixture was cooled, quenched with ice and extracted with DCM. The organic layer was dried over Na2S04 and evaporated under reduced pressure to afford product XIII in 75percent yield.

The synthetic route of 4442-53-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AGIOS PHARMACEUTICALS, INC.; SALITURO, Francesco, G.; SAUNDERS, Jeffrey, O.; WO2011/72174; (2011); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem