Application of 39270-39-8, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 39270-39-8, Name is (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanol,introducing its new discovery.
Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity
Gaucher disease is a lysosomal storage disorder (LSD) caused by deficiency in the enzyme glucocerebrosidase (GC). Small molecule chaperones of protein folding and translocation have been proposed as a promising therapeutic approach to this LSD. Most small molecule chaperones described in the literature contain an iminosugar scaffold. Here we present the discovery and evaluation of a new series of GC inhibitors with a quinazoline core. We demonstrate that this series can improve the translocation of GC to the lysosome in patient-derived cells. To optimize this chemical series, systematic synthetic modifications were performed and the SAR was evaluated and compared using three different readouts of compound activity: enzymatic inhibition, enzyme thermostabilization, and lysosomal translocation of GC.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 39270-39-8, and how the biochemistry of the body works.Application of 39270-39-8
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Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem