With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2879-20-1,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,as a common compound, the synthetic route is as follows.
The 178mg (1mmol) 6- acetyl-1,4-benzo-dioxane, 80mg (2mmol) sodium hydroxide was placed in 50mLSingle neck flask was added 10mL of ethanol and dissolved; the 280mg (0.97mmol) 2- fluoro -4- (9- (9H- carbazol-yl))Benzaldehyde was dissolved in 10mL of dichloromethane, ethanol and added dropwise to the mixture, stirred at room temperature overnight, filtered,Ethanol, washed with petroleum ether and dried to give a pale yellow solid (LJZ-6-18) 386mg, 89% yield.
The synthetic route of 2879-20-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Institute of Materia Medica Chinese Academy of Medical Sciences; Xiaozhi, Yan; Ye, Fei; Guo, Zongru; Tianjin, Ying; Liu, Junzheng; Zhang, Shuen; Nie, Feilin; Tao, Rongya; Zhang, Xiaolin; Liu, Junchang; He, Yibo; Ma, Yiming; (36 pag.)CN102382037; (2016); B;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem