With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2879-20-1,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,as a common compound, the synthetic route is as follows.
The specific steps are: Add compound 10 (0.5 mmol) to a 38 mL pressure tube. After iodine (0.25 mmol) and 2 mL of DMSO were subjected to a first reaction at 100 C for 90 min, 2-aminobenzonitrile (0.4 mmol) was added to the reaction mixture. KHS¡¤H2O (1 mmol) was subjected to a second reaction at 90 C, after 20 hours, The reaction mixture was extracted with ethyl acetate. The organic layer was washed with saturated sodium sulfate The solvent is distilled off under reduced pressure to obtain a crude product. Crude products with petroleum ether and ethyl acetateThe mixture is purified by column chromatography to obtain a yellow liquid. The total yield was 69%.
The synthetic route of 2879-20-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Central China Normal University; Geng Xiao; Wu Xia; Wu Yandong; Wu Anxin; (15 pag.)CN109232366; (2019); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem