With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.274910-19-9,(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol,as a common compound, the synthetic route is as follows.
2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol (533 mg, 3.20 mmol) is dissolved in chloroform (4 mL), pyridine (0.11 mL) and thionyl chloride (0.7 mL, 9.7 mmol) is added little by little and the mixture is stirred at room temperature for 1 hour. The reaction solution is added with water and extracted with dichloromethane, and the organic layer is washed with aqueous sodium hydrogen carbonate solution. The organic layer is dried, the solvent is distilled off under reduced pressure, and pale yellow liquid of 578 mg is obtained in 97% yield.
The synthetic route of 274910-19-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; KANTO KAGAKU KABUSHIKI KAISHA; ABE, Jiro; INAGAKI, Yuki; SUGA, Takayoshi; NAGASAWA, Hiroto; US2020/131193; (2020); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem