With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17413-10-4,(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanamine,as a common compound, the synthetic route is as follows.,17413-10-4
General procedure: To a magnetically stirred solution of 2-chloro-5-(trifluoromethyl)-3-nitrobenzamide (8, prepared according to the reportedmethod [11]) (1.07 g, 4.0 mmol) in dry 1,2-dichloroethane(10 mL) was added oxalyl chloride (863 mg, 6.8 mmol). The mixturewas heated to reflux for 3 h under an atmosphere of argon. Thesolvent was evaporated under reduced pressure. The residue wasdissolved in acetonitrile (15 mL) and then cooled to -25 C. Correspondingamine (4.0 mmol) in acetonitrile (5 mL) was slowlyadded to the above solution keeping the reaction under -25 C for 0.5-2 h. The precipitated solid was filtered, washed with cooledacetonitrile and dried. The crude product was purified by silica gelcolumn chromatography (EtOAc: PE = 1:2) to obtain the intermediates9a-r.
The synthetic route of 17413-10-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Li, Peng; Wang, Bin; Zhang, Xinwei; Batt, Sarah M.; Besra, Gurdyal S.; Zhang, Tingting; Ma, Chen; Zhang, Dongfeng; Lin, Ziyun; Li, Gang; Huang, Haihong; Lu, Yu; European Journal of Medicinal Chemistry; vol. 160; (2018); p. 157 – 170;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem