Safety of 5,5′-Dimethyl-2,2′-bipyridine. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5,5′-Dimethyl-2,2′-bipyridine, is researched, Molecular C12H12N2, CAS is 1762-34-1, about Construction and structure studies of DNA-bipyridine complexes as versatile scaffolds for site-specific incorporation of metal ions into DNA. Author is Wang, Rui; Ranganathan, Srivathsan V.; Haruehanroengra, Phensinee; Mao, Song; Scalabrin, Matteo; Fabris, Daniele; Chen, Alan; Liu, Hehua; Hassan, Abdalla E. A.; Gan, Jianhua; Sheng, Jia.
The facile construction of metal-DNA complexes using ‘Click’ reactions is reported here. A series of 2′-propargyl-modified DNA oligonucleotides were initially synthesized as structure scaffolds and were then modified through ‘Click’ reaction to incorporate a bipyridine ligand equipped with an azido group. These metal chelating ligands can be placed in the DNA context in site-specific fashion to provide versatile templates for binding various metal ions, which are exchangeable using a simple EDTA washing-and-filtration step. The constructed metal-DNA complexes were found to be thermally stable. Their structures were explored by solving a crystal structure of a propargyl-modified DNA duplex and installing the bipyridine ligands by mol. modeling and simulation. These metal-DNA complexes could have wide applications as novel organometallic catalysts, artificial RNases, and potential metal delivery systems.
Although many compounds look similar to this compound(1762-34-1)Safety of 5,5′-Dimethyl-2,2′-bipyridine, numerous studies have shown that this compound(SMILES:CC1=CN=C(C=C1)C1=NC=C(C)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.