Reactions catalyzed interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend on composition, collectively referred to as solvent effects. In a patent£¬Which mentioned a new discovery about Formula: C8H9NO2, Formula: C8H9NO2
The presented study comprises the synthesis of a new series of ethylated sulfonamides in which 1,4- benzodioxane moietyhas been incorporated. The reaction of 1,4-benzodioxane-6-amine (1) with ethane sulfonyl chloride (2) yielded N-(2,3-dihydrobenzo[1,4]dioxin-6-yl)ethanesulfonamide (3), which further on treatment with various alkyl/aralkyl halides, 4a-r, in N,N?-dimethylformamide (DMF) and in the presence of lithium hydride (LiH) acting as a weak base and catalyst;yielded derivativesofN-alkyl/aralkyl substituted N-(2,3-dihydrobenzo[1,4]dioxin-6- yl)ethanesulfonamides (5a-r). The characterization of these derivatives was carried out by different spectroscopic techniques like infra red, proton-NMR and mass spectrometry; then screened against various enzymes i.e. acetylcholinesterase, butyrylcholinesterase, lipoxygenase and alpha-glucosidase enzymes and five different bacterial strains. The synthesized compounds were found to be good inhibitors of lipoxygenase but moderate inhibitors of AChE, BChE and a-glucosidase; whereas compounds 3, 5a, 5f, 5n and 5r were found good antibacterial compounds. The interaction between inhibitors and target enzymes (cholinestrases and lipoxygenase) was computationally observed which correlated with the experimental results.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Formula: C8H9NO2, you can also check out more blogs about22013-33-8
Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem