4442-53-9, Name is 2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid, belongs to benzodioxans compound, is a common compound. Application In Synthesis of 2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acidIn an article, once mentioned the new application about 4442-53-9.
Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles
Replacing the naphthalene C-unit of the anti-tuberculosis drug bedaquiline with a range of bicyclic heterocycles of widely differing lipophilicity gave analogs with a 4.5-fold range in clogP values. The biological results for these compounds indicate on average a lower clogP limit of about 5.0 in this series for retention of potent inhibitory activity (MIC90s) against M.tb in culture. Some of the compounds also showed a significant reduction in inhibition of hERG channel potassium current compared with bedaquiline, but there was no common structural feature that distinguished these.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 4442-53-9
Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem