22013-33-8, Name is 2,3-Dihydrobenzo[b][1,4]dioxin-6-amine, belongs to benzodioxans compound, is a common compound. Quality Control of 2,3-Dihydrobenzo[b][1,4]dioxin-6-amineIn an article, once mentioned the new application about 22013-33-8.
Antitumor agents. 123. Synthesis and human DNA topoisomerase II inhibitory activity of 2′-chloro derivatives of etoposide and 4beta-(arylamino)-4′-O- demethylpodophyllotoxins
The 2′-chloro derivatives of etoposide and 4beta-(arylamino)-4′-O- demethylpodophyllotoxins have been synthesized and evaluated for their inhibitory activity against the human DNA topoisomerase II as well as for their activity in causing cellular protein-linked DNA breakage. The results showed that none of the compounds are active as a result of the C-2′ chloro substitution on ring E. This would suggest that the free rotation of ring E is essential for the aforementioned enzyme inhibitory activity. In addition, these 2′-chloro derivatives showed no significant cytotoxicity (KB).
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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem