An article Chalcone derivatives bearing chromen or benzo[f]chromen moieties: Design, synthesis, and evaluations of anti-inflammatory, analgesic, selective COX-2 inhibitory activities WOS:000471750200009 published article about BIOLOGICAL EVALUATION; MOLECULAR DOCKING; AGENTS SYNTHESIS; IN-VITRO; ANALOGS; ESTERS in [Fu, Zhi-Yang; Qu, Yu-Le; Guan, Li-Ping] Zhejiang Ocean Univ, Food & Pharm Coll, Zhoushan 316022, Zhejiang, Peoples R China; [Jin, Qing-Hao] Zhejiang Ocean Univ, Donghai Sci & Technol Coll, Zhoushan 316000, Zhejiang, Peoples R China in 2019.0, Cited 28.0. HPLC of Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6
Thirty-eight chalcone derivatives bearing a chromen or benzo[f]chromen moiety were synthesized and evaluated for their anti-inflammatory and analgesic activities. Using an ear edema model, anti-inflammatory activities were observed for compounds 3a-3s (ear inflammation: 1.75-3.71 mg) and 4a-4s (ear inflammation: 1.71-4.94 mg). All compounds also displayed analgesic effects with inhibition values of 66.7-100% (3a-3s) and 96.2-100% (4a-4s). The 12 compounds that displayed excellent anti-inflammatory and analgesic effects were tested for their inhibitory activity against ovine COX-1 and COX-2. Six compounds bearing a chromen moiety were weak inhibitors of the COX-1 isozyme but showed moderate COX-2 isozyme inhibitory effects (IC(50)s from 0.37 mu M to 0.83 mu M) and COX-2 selectivity indexes (SI: 22.49-9.34). Those bearing a benzo[f]chromen moiety were more selective toward COX-2 than those bearing a chromen moiety with IC(50)s from 0.25 mu M to 0.43 mu M and COX-2 selectivity indexes from SI: 31.08 to 20.67.
Welcome to talk about 100-19-6, If you have any questions, you can contact Fu, ZY; Jin, QH; Qu, YL; Guan, LP or send Email.. HPLC of Formula: C8H7NO3
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem