Gavande, NS; VanderVere-Carozza, PS; Pawelczak, KS; Vernon, TL; Jordan, MR; Turchi, JJ in [Gavande, Navnath S.; VanderVere-Carozza, Pamela S.; Vernon, Tyler L.; Jordan, Matthew R.; Turchi, John J.] Indiana Univ Sch Med, Indianapolis, IN 46202 USA; [Gavande, Navnath S.] Wayne State Univ, Coll Pharm & Hlth Sci, Detroit, MI 48202 USA; [Pawelczak, Katherine S.; Turchi, John J.] NERx Biosci, Indianapolis, IN 46202 USA published Structure-Guided Optimization of Replication Protein A (RPA)-DNA Interaction Inhibitors in 2020, Cited 32. SDS of cas: 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.
Replication protein A (RPA) is the major human single stranded DNA (ssDNA)-binding protein, playing essential roles in DNA replication, repair, recombination, and DNA-damage response (DDR). Inhibition of RPA-DNA interactions represents a therapeutic strategy for cancer drug discovery and has great potential to provide single agent anticancer activity and to synergize with both common DNA damaging chemotherapeutics and newer targeted anticancer agents. In this letter, a new series of analogues based on our previously reported TDRL-551 (4) compound were designed to improve potency and physicochemical properties. Molecular docking studies guided molecular insights, and further SAR exploration led to the identification of a series of novel compounds with low micromolar RPA inhibitory activity, increased solubility, and excellent cellular up-take. Among a series of analogues, compounds 43, 44, 45, and 46 hold promise for further development of novel anticancer agents.
SDS of cas: 100-19-6. Welcome to talk about 100-19-6, If you have any questions, you can contact Gavande, NS; VanderVere-Carozza, PS; Pawelczak, KS; Vernon, TL; Jordan, MR; Turchi, JJ or send Email.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem