4442-53-9, With the rapid development of chemical substances, we look forward to future research findings about 4442-53-9
The benzodioxans compound, cas is 4442-53-9 name is 2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid, mainly used in chemical industry, its synthesis route is as follows.
A.5.1 Synthesis of (IS^S.SRJ^-facylamino-methylJ-S-aza-bicycloIS.S.O]- octane-3-carboxylic acid tert. -butyl ester derivatives (general procedure)To a solution of the respective carboxylic acid R3-COOH (1 eq) in DMF (0.2 mmol/ 0.5 mL) are added successively DIPEA (5 eq) and TBTU (1 eq). The reaction mixture is stirred for 15 min. at RT and then is added a solution of (1S,2S,5R)-1- aminomethyl-3-aza-bicyclo[3.3.0]-octane-3-carboxylic acid te/t.-butyl ester derivative (1 eq) in DMF (0.5 ml_). The stirring at RT is continued for 16 h, the reaction mixture is poured into water and diluted with EA. The org. phase is washed with sat. NaHCOs solution and water. After drying over anh. MgSO4 and removal of solvents in vacuo the desired compounds are obtained which are used without further purification.(1S,2S,5R)-2-{[(3,4-Dihydro-benzo[1 ,4]dioxine-5-carbonyl)-amino]-methyl}-3- aza-bicyclo[3.3.0]octane-3-carboxylic acid tert. -butyl esterprepared by reaction of (I S^S.SR^I-aminomethyl-S-aza-bicyclobeta.S.OJ-octane-S- carboxylic acid te/t-butyl ester with commercially available 2,3-dihydro- benzo[1 ,4]dioxine-5-carboxylic acid.LC-MS: tR = 1.00 min; [M+H]+ = 403.
4442-53-9, With the rapid development of chemical substances, we look forward to future research findings about 4442-53-9
Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/4584; (2009); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem