So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Cedillo-Gutierrez, Erika Lorena; Hernandez-Ayala, Luis Felipe; Torres-Gutierrez, Carolina; Reina, Miguel; Flores-Alamo, Marcos; Carrero, Julio C.; Ugalde-Saldivar, Victor M.; Ruiz-Azuara, Lena researched the compound: 5,5′-Dimethyl-2,2′-bipyridine( cas:1762-34-1 ).Quality Control of 5,5′-Dimethyl-2,2′-bipyridine.They published the article 《Identification of descriptors for structure-activity relationship in ruthenium (II) mixed compounds with antiparasitic activity》 about this compound( cas:1762-34-1 ) in European Journal of Medicinal Chemistry. Keywords: preparation ruthenium pyridyldithioctane bipyridine phenanthroline salicylaldehydate chloro complex; crystal mol structure ruthenium pyridyldithioctane bipyridine phenanthroline salicylaldehydate complex; cyclic voltammetry ruthenium pyridyldithioctane bipyridine phenanthroline salicylaldehydate chloro complex; antiparasitic activity ruthenium pyridyldithioctane bipyridine phenanthroline salicylaldehydate chloro complex; Amebiasis; Amoebicidal activity; DFT calculations; Ruthenium (II) mixed complexes; SAR studies. We’ll tell you more about this compound (cas:1762-34-1).
Herein is presented the synthesis, characterization, electrochem. studies, DFT calculations and in vitro evaluation of amoebicidal activity in trophozoites of Entamoeba histolytica of twenty ruthenium(II) mixed compounds with general formulas: [Ru(pdto)(E-E)]Clx (E-E bidentate, either neutral or neg. charged ligands). For compounds under study, O-O, N-O and N-N auxiliary donor ligands demonstrate to have a crucial impact on the electronic properties and that it is possible to modulate the antiparasitic activity. Among analyzed complexes, only four present a better performance compared to typically used metronidazole drug (IC50 < 6.80μmol/L) to treat amebiasis disease. For studied compounds, structure-activity relations are strongly determined by either the redox potential (E1/2) of RuII/RuIII and calculated molar volume (V) of the complexes. Here is a brief introduction to this compound(1762-34-1)Quality Control of 5,5′-Dimethyl-2,2′-bipyridine, if you want to know about other compounds related to this compound(1762-34-1), you can read my other articles.