An article Biocompatibility, in Vitro Antiproliferative, and in Silico EGFR/VEGFR2 Studies of Heteroleptic Metal(II) Complexes of Thiosemicarbazones and Naproxen WOS:000482173200010 published article about MIXED-LIGAND COMPLEXES; DNA INTERACTION; ANTICANCER ACTIVITY; ZINC(II) COMPLEXES; MOLECULAR DOCKING; GROWTH-INHIBITION; CANCER-CELLS; COPPER(II); NICKEL(II); BINDING in [Bharathi, Sundaram; Mahendiran, Dharmasivam; Rahiman, Aziz Kahlur] Univ Madras, New Coll Autonomous, Postgrad & Res Dept Chem, Chennai 600014, Tamil Nadu, India; [Mahendiran, Dharmasivam] Univ Sydney, Bosch Inst, Dept Pathol, Mol Pharmacol & Pathol Program, Sydney, NSW 2006, Australia; [Kumar, Raju Senthil] Swamy Vivekanandha Coll Pharm, Dept Pharmaceut Chem, Elayampalayam 637205, Tiruchengodu, India; [Kim, Young Guk; Gajendiran, Mani; Kim, Kyobum] Incheon Natl Univ, Sch Life Sci & Bioengn, Div Bioengn, Incheon 22012, South Korea in 2019.0, Cited 48.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Computed Properties of C8H7NO3
Eight heteroleptic nickel(II) and copper(II) complexes of the type [M(L1-4)(nap)(2)] (1-8), where L1-4 = 2-(1-(4-substitutedphenyl)ethylidene)-hydrazinecarbothioamide, nap = naproxen, and M = Ni(II) or Cu(II), have been synthesized and characterized. UV-vis and EPR spectral studies showed distorted octahedral geometry around metal(II) ions. The cyclic voltammogram of complexes 1-8 displayed an irreversible one-electron transfer process in the cathodic region (E-pc = -0.66 to -1.43 V), and nickel(II) complexes 1-4 displayed an irreversible one-electron oxidation process in the anodic region (E-pa = 0.75 to 1.10 V). The obtained magnetic moment values (1.82-1.93 mu(B)) for copper(II) complexes 5-8 indicate distortion from octahedral geometry, which is further supported by EPR studies. The geometry of the complexes is retained in both solid and solution phases as evidenced from UV-vis and EPR studies. All the complexes showed stability for almost 72 h in biologically relevant solutions. The reducing ability of the copper(II) complexes in the presence of ascorbic acid was analyzed by UV-vis and cyclic voltammetry techniques, which indicates the reduction of the copper(II) to a copper(I) center, and possible interaction within the cells. An in vitro antiproliferative study revealed the nontoxic nature of complexes to normal human dermal fibroblast (NHDF) up to a concentration of 100 ng/mL. The antiproliferative activity of the complexes was tested against three cancerous (human breast adenocarcinoma (MCF-7), hepatoma (HepG2), and lung (A549)) cell lines using MTT reduction assay, which showed enhanced activity for complexes 4 and 8 containing the hydrophobic substituent. Apoptotic and cellular uptake studies showed that complex 8 is readily taken up by HepG2 cell lines and induces ROS-mediated mitochondrial and caspase-dependent apoptosis. In silico studies indicated hydrogen bonding, hydrophobic, and pi-pair (pi-pi, pi-sigma, and pi-cation) interactions between the complexes and EGFR/VEGFR2 kinase receptors.
Computed Properties of C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Bharathi, S; Mahendiran, D; Kumar, RS; Kim, YG; Gajendiran, M; Kim, K; Rahiman, AK or concate me.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem