Reactions catalyzed interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend on composition, collectively referred to as solvent effects. In a patent，Which mentioned a new discovery about HPLC of Formula: C9H8O4, HPLC of Formula: C9H8O4
A series of 2-styryl-5-nitroimidazole derivatives containing 1,4-benzodioxan moiety (3a-3r) has been designed, synthesized and their biological activities were also evaluated as potential antiproliferation and focal adhesion kinase (FAK) inhibitors. Among all the compounds, 3p showed the most potent activity in vitro which inhibited the growth of A549 with IC 50 value of 3.11 muM and Hela with IC50 value of 2.54 muM respectively. Compound 3p also exhibited significant FAK inhibitory activity (IC50 = 0.45 muM). Docking simulation was performed for compound 3p into the FAK structure active site to determine the probable binding model.
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