Chemistry is traditionally divided into organic and inorganic chemistry. category: benzodioxans, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 22013-33-8
Synthesis, characterization and biological screening of some new sulfonamides derivatives of 1,4-benzodioxane-6-amine
In the present study, a series of N-substituted derivatives of 1,4-benzodioxane-6-amine have been synthesized. The reaction of 1,4-benzodioxane-6-amine (1) with various alkyl/aryl sulfonyl chlorides (2a-k) yielded N-alkyl/aryl sulfonamides (3a-k), which further on treatment with benzyl chloride (4) in the presence of sodium hydride furnished into N-benzylated sulfonamides (6a-k) while the reaction of 3a-k with ethyl iodide (5 ) yielded N-ethylated sulfonamides 7a-k. These derivatives were characterized by IR, 1H-NMR and EI-MS and then screened against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and lipoxygenase (LOX) enzymes and were found to be good inhibitors of lipoxygenase only. The interaction between inhibitors and target enzymes were computationally observed which correlates with the experimental results.
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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem