The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5,5′-Dimethyl-2,2′-bipyridine( cas:1762-34-1 ) is researched.Synthetic Route of C12H12N2.Gomez-Gonzalez, Jacobo; Bouzada, David; Perez-Marquez, Lidia A.; Sciortino, Giuseppe; Marechal, Jean-Didier; Vazquez Lopez, Miguel; Vazquez, M. Eugenio published the article 《Stereoselective self-assembly of DNA binding helicates directed by the viral β-annulus trimeric peptide motif》 about this compound( cas:1762-34-1 ) in Bioconjugate Chemistry. Keywords: peptide solid phase synthesis bipyridine self assembly chiral helicate; chiral peptide helicate complexation iron DNA binding; bipyridine peptide supramol structure MD simulation fluorescence; iron complex peptide stability. Let’s learn more about this compound (cas:1762-34-1).
Combining coordination chem. and peptide engineering offers extraordinary opportunities for developing novel mol. (supra)structures. Here, we demonstrate that the β-annulus motif is capable of directing the stereoselective assembly of designed peptides containing 2,2′-bipyridine ligands into parallel three-stranded chiral peptide helicates, and that these helicates selectively bind with high affinity to three-way DNA junctions.
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