Desai, NC; Vaja, DV; Joshi, SB; Khedkar, VM in [Desai, Nisheeth C.; Vaja, Darshita V.; Joshi, Surbhi B.] Maharaja Krishnakumarsinhji Bhavnagar Univ, Div Med Chem, Dept Chem DST FIST & UGC NON SAP, Mahatma Gandhi Campus, Bhavnagar 364002, Gujarat, India; [Khedkar, Vijay M.] Vishwakarma Univ, Dept Pharmaceut Chem, Sch Pharm, Pune 411048, Maharashtra, India published Synthesis and molecular docking study of pyrazole clubbed oxazole as antibacterial agents in 2021.0, Cited 20.0. SDS of cas: 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.
We have developed a simple synthetic protocol for the preparation of novel 3-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-5-arylisoxazoles. The structure of synthesized compounds was elucidated by spectral techniques like FT-IR,H-1-NMR,C-13-NMR, and mass. The novel bioactive compounds3a-twere evaluated for in vitro antibacterial activity on several bacterial species. Compounds3c(-4-NO2),3o(-4-F), and3r(-3,4-Cl-2) exhibited good in vitro antibacterial activity. Furthermore, molecular docking on DNA gyrase subunit bcould shed some light on the mechanism of action which can serve as a guide for lead optimization. Graphic abstract
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Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem