An article NOVEL SYNTHESIS OF PYRAZOLE-CONTAINING THIOPHENE, 2-ALKYLOXY-PYRIDINE AND THIENO[2,3-d]PYRIMIDINE SCAFFOLDS AS ANALGESIC AGENTS WOS:000496971800011 published article about BIOLOGICAL EVALUATION; DERIVATIVES; DESIGN; INHIBITION; DOCKING; ANALOGS; SAR in [Khalifa, Nagy M.] King Saud Univ, Coll Pharm, Pharmaceut Chem Dept, Drug Explorat & Dev Chair DEDC, Riyadh 11451, Saudi Arabia; [Khalifa, Nagy M.; Fahmy, Hoda H.] Natl Res Ctr, Therapeut Chem Dept, Pharmaceut & Drug Ind Div, Giza, Egypt; [Nossier, Eman S.] Al Azhar Univ Girls, Fac Pharm, Pharmaceut Chem Dept, Cairo, Egypt; [Amr, Abd El-Galil E.] Natl Res Ctr, Appl Organ Chem Dept, Giza 12622, Egypt; [Herqash, Rashed N.] King Saud Univ, Coll Pharm, Pharmaceut Chem Dept, Riyadh 11451, Saudi Arabia in 2019.0, Cited 31.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Product Details of 100-19-6
A group of trisubstituted pyrazoles containing thiophen, 2-alkyloxypyridine and thieno[2,3-d]pyrimidine heterocycles were synthesized in a study for possible analgesic agents. The desired products were obtained by reaction of 2-(1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-4-yemethylene)malononitrile with sulfur in presence of TEA, followed by treatment with different reagents. Newer products were examined for their analgesic properties, among them, analog 7 showed significant analgesic effects in comparison with reference medicines activity.
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Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem