Quality Control of 1-(4-Nitrophenyl)ethanone. Bangalore, PK; Vagolu, SK; Bollikanda, RK; Veeragoni, DK; Choudante, PC; Misra, S; Sriram, D; Sridhar, B; Kantevari, S in [Bangalore, Pavan K.; Bollikanda, Rakesh K.; Kantevari, Srinivas] CSIR Indian Inst Chem Technol, Fluoro & Agrochem Div, Hyderabad 500007, Telangana, India; [Bangalore, Pavan K.; Bollikanda, Rakesh K.] CSIR Indian Inst Chem Technol, Acad Sci & Innovat Res AcSIR, Hyderabad 500007, Telangana, India; [Veeragoni, Dileep K.; Choudante, Pallavi C.; Misra, Sunil] CSIR Indian Inst Chem Technol, Appl Biol Div, Hyderabad 500007, Telangana, India; [Sridhar, Balasubramanian] CSIR Indian Inst Chem Technol, Xray Crystallog Div, Hyderabad 500007, Telangana, India; [Vagolu, Siva K.; Sriram, Dharmarajan] Birla Inst Technol & Sci Pilani, Med Chem & Antimycobacterial Res Lab, Pharm Grp, Hyderabad 500078, Telangana, India published Usnic Acid Enaminone-Coupled 1,2,3-Triazoles as Antibacterial and Antitubercular Agents in 2020, Cited 51. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.
(+)-Usnic acid, a product of secondary metabolism in lichens, has displayed a broad range of biological properties such as antitumor, antimicrobial, antiviral, anti-inflammatory, and insecticidal activities. Interested by these pharmacological activities and to tap into its potential, we herein present the synthesis and biological evaluation of new usnic acid enaminone-conjugated 1,2,3-triazoles 10-44 as antimycobacterial agents. (+)-Usnic acid was condensed with propargyl amine to give usnic acid enaminone 8 with a terminal ethynyl moiety. It was further reacted with various azides A1-A35 under copper catalysis to give triazoles 10-44 in good yields. Among the synthesized compounds, saccharin derivative 36 proved to be the most active analogue, inhibiting Mycobacterium tuberculosis (Mtb) at an MIC value of 2.5 mu M. Analogues 16 and 27, with 3,4-difluorophenacyl and 2-acylnaphthalene units, respectively, inhibited Mtb at MIC values of 5.4 and 5.3 mu M, respectively. Among the tested Gram-positive and Gram-negative bacteria, the new derivatives were active on Bacillus subtilis, with compounds 18 [3-(trifluoromethyl)phenacyl] and 29 (N-acylmorpholinyl) showing inhibitory concentrations of 41 and 90.7 mu M, respectively, while they were inactive on the other tested bacterial strains. Overall, the study presented here is useful for converting natural (+)-usnic acid into antitubercular and antibacterial agents via incorporation of enaminone and 1,2,3-triazole functionalities.
Quality Control of 1-(4-Nitrophenyl)ethanone. Welcome to talk about 100-19-6, If you have any questions, you can contact Bangalore, PK; Vagolu, SK; Bollikanda, RK; Veeragoni, DK; Choudante, PC; Misra, S; Sriram, D; Sridhar, B; Kantevari, S or send Email.
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Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem