Iqbal, S; Khan, MA; Ansari, Z; Jabeen, A; Faheem, A; Fazal-Ur-Rehman, S; Basha, FZ in [Iqbal, Shazia; Khan, Maria A.; Basha, Fatima Z.] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan; [Ansari, Zulqarnain; Fazal-Ur-Rehman, Saba] Univ Karachi, Dept Chem, Karachi, Pakistan; [Jabeen, Almas; Faheem, Aisha] Univ Karachi, Int Ctr Chem & Biol Sci, PCMD, Karachi, Pakistan published Synthesis of new bicarbazole-linked triazoles as non-cytotoxic reactive oxygen species (ROS) inhibitors in 2019.0, Cited 37.0. Application In Synthesis of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.
Carbazole analogs 3 and 4 and a new library of bicarbazole-linked triazoles 6-11 were prepared via new synthetic methodology. Metal-catalyzed oxidative coupling reaction was utilized for the synthesis of bicarbazole acetylene 4 and different metals (Zn+2, Co+2, Fe+3, Ni+2, Cu+2, Mn+2) as catalyst were screened. Only Fe-catalyzed reaction was found to be excellent and gave homocoupled product 4. Cu-catalyzed 1,3-dipolar cycloaddition was also utilized to install triazole moiety for the synthesis of hybrid molecules 6-11. Based on reported anti-inflammatory activity of carbazole and triazole scaffolds, all compounds were screened for their reactive oxygen species (ROS) inhibitory potential. Results from these studies revealed triazole 9 as most active compound (IC50 value of 7.6 +/- 0.1 mu g/mL on human whole blood and 2.7 +/- 0.09 mu g/mL on isolated neutrophils) using ibuprofen as a standard. Therefore, class described herein can serve as attractive structural element for further studies on ROS inhibition.
Application In Synthesis of 1-(4-Nitrophenyl)ethanone. Welcome to talk about 100-19-6, If you have any questions, you can contact Iqbal, S; Khan, MA; Ansari, Z; Jabeen, A; Faheem, A; Fazal-Ur-Rehman, S; Basha, FZ or send Email.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem