An article Molecular Hybrids Integrated with Benzimidazole and Pyrazole Structural Motifs: Design, Synthesis, Biological Evaluation, and Molecular Docking Studies WOS:000530659700050 published article about 2 CHK2 INHIBITORS; POTENTIAL ANTICANCER; CARBAZOLES SYNTHESIS; DERIVATIVES; DISCOVERY; SCAFFOLD; BENDAMUSTINE; MOIETY; DRUGS in [Sivaramakarthikeyan, Ramar; Shunmugam, Iniyaval; Vadivel, Saravanan; Ramalingan, Chennan] Kalasalingam Acad Res & Educ Deemed Be Univ, Sch Adv Sci, Dept Chem, Krishnankoil 626126, Tamil Nadu, India; [Lim, Wei Meng; Mai, Chun-Wai] Int Med Univ, Sch Pharm, Kuala Lumpur 57000, Malaysia; [Mai, Chun-Wai] Int Med Univ, Ctr Canc & Stem Cell Res, Inst Res Dev & Innovat IRDI, Kuala Lumpur 57000, Malaysia in 2020.0, Cited 67.0. Recommanded Product: 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6
Synthesis of a series of benzimidazole-ornamented pyrazoles, 6a-6j has been obtained from arylhydrazine and aralkyl ketones via a multistep synthetic strategy. Among them, a hybridpossessing para-nitrophenyl moiety connected to a pyrazole scaffold (6a) exerted the highest anti-inflammatory activity, which is superior to the standard, diclofenac sodium. While executing the 2,2-diphenyl-1-picrylhydrazyl radical-scavenging activity, a hybrid-possessing para-bromophenyl unit integrated at the pyrazole structural motif (6i) exhibited the highest activity among the hybrids examined. Besides, evaluation of anticancer potency of the synthesized hybrids revealed that the one containing a para-fluorophenyl unit tethered at the pyrazole nucleus (6h) showed the highest activity against both the pancreatic cancer cells (SW1990 and AsPCl) investigated. Considerable binding affinity between B-cell lymphoma and the hybrid, 6h has been reflected while performing molecular docking studies (-8.65 kcal/mol). The outcomes of the investigation expose that these hybrids could be used as effective intermediates to construct more potent biological agents.
Recommanded Product: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Sivaramakarthikeyan, R; Shunmugam, I; Vadivel, S; Lim, WM; Mai, CW; Ramalingan, C or concate me.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem