A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Application In Synthesis of 5-Azacytosine, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 931-86-2, Name is 5-Azacytosine, molecular formula is C3H4N4O. In an article, author is Ali, HM,once mentioned of 931-86-2.
Selectivity, acetylcholinesterase inhibition kinetics, and quantitative structure-activity relationships of a series of N-(2-oxido-1,3,2-benzodioxa-phosphol-2-yl) amino acid ethyl or diethyl esters
The inhibitory effects of a recently introduced series of the titled compounds on insect and mammalian acetylcholinesterase (AChE) activity were examined, where the median inhibition concentration (I-50) and the inhibition kinetic parameters, bimolecular inhibition rate constant (k(i)), affinity constant (K-a), and phosphorylation rate constant (k(p)), were determined for each compound. Results indicated that all examined dioxaphospholenes had less inhibitory effects on mammalian AChE than fenitrothion, a commercial pesticide with moderate mammalian toxicity. The highest selectivity was obtained with compounds containing glutamic and leucine moieties (2.70 and 2.18, respectively) while selectivity of fenitrothion was 0.93. The low inhibitory effects of the examined dioxaphospholenes on mammalian AChE were attributed to their low phosphorylation rates(k(p) < 2.2 min(-1)) compared to that of fenitrothion (k(p) = 4.84 min(-1)). QSAR equations indicated that the inhibition process is controlled mainly by both the phosphorylation rate (direct effect) and the affinity of compounds toward the enzyme (inverse effect). Although the compounds' hydrophobicity had no effects on the inhibition process, it affects the compounds' toxicity since it affects the ability of compounds to penetrate insects to reach the enzyme active site. (c) 2005 Elsevier Inc. All rights reserved. If you¡¯re interested in learning more about 931-86-2. The above is the message from the blog manager. Application In Synthesis of 5-Azacytosine.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem